Nontraumatic determination of left ventricular ejection fraction by radionuclide angiocardiography

Previous reports have suggested that left ventricular ejection fraction can be assessed by recording the passage of peripherally administered radioactive bolus through the heart. The accuracy and validity of this technique were examined in 20 patients undergoing diagnostic cardiac catheterization. 9...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1975-05, Vol.51 (5), p.902-909
Main Authors: Schelbert, H R, Verba, J W, Johnson, A D, Brock, G W, Alazraki, N P, Rose, F J, Ashburn, W L
Format: Article
Language:English
Subjects:
Adult
Aged
Angiocardiography
Aortic Valve Insufficiency - physiopathology
Aortic Valve Stenosis - physiopathology
Cardiac Catheterization
Cardiac Output - methods
Cardiac Volume
Cineangiography
Computers
Coronary Disease - physiopathology
Humans
Middle Aged
Mitral Valve Insufficiency - physiopathology
Mitral Valve Stenosis - physiopathology
Radionuclide Imaging - methods
Serum Albumin
Technetium
Ventricular Function
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Summary:Previous reports have suggested that left ventricular ejection fraction can be assessed by recording the passage of peripherally administered radioactive bolus through the heart. The accuracy and validity of this technique were examined in 20 patients undergoing diagnostic cardiac catheterization. 99m-Tc-human serum albumin was injected via a central venous catheter into the superior vena cava and precordial activity recorded with a gamma scintillation camera interfaced to a small digital computer. A computer program was designed to generate time-activity curves from the left ventricular blood pool and to calculate left ventricular ejection fractions from the cyclic fluctuations of the left ventricular time-activity curve which correspond to left ventricular volume changes during each cardiac cycle. The results correlated well with those obtained by biplane cineangiocardiography (r equals 0.94) and indicated that the technique should allow accurate and reproducible determination of left ventricular ejection fraction. The findings, however, demonstrated that the time-activity curve must be generated from a region-of-interest which fits the left ventricular blood pool precisely and must be corrected for contributions arising from noncardiac background structures. This nontraumatic and potentially noninvasive technique appears particularly useful for serial evaluation of the acutely ill patient and for follow-up studies in nonhospitalized patients.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.51.5.902