β-Adrenergic stimulation of cyclic AMP and protein kinase activity in the thyroid

THE demonstration that the sympathetic nervous system can have a direct effect on the thyroid 1 , and the increasing clinical use of adrenergic blocking agents in thyrotoxicosis have reawakened interest in the effects of catecholamines on the thyroid. We have therefore compared the effects of thyroi...

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Bibliographic Details
Published in:Nature (London) 1975-03, Vol.254 (5498), p.347-349
Main Authors: SPAULDING, STEPHEN W, BURROW, GERARD N
Format: Article
Language:English
Subjects:
Animals
Cattle
Cyclic AMP - metabolism
Dose-Response Relationship, Drug
Humanities and Social Sciences
In Vitro Techniques
Isoproterenol - pharmacology
letter
multidisciplinary
Phentolamine - pharmacology
Propranolol - pharmacology
Protein Kinases - metabolism
Science
Science (multidisciplinary)
Stimulation, Chemical
Thyroid Gland - enzymology
Thyroid Gland - metabolism
Thyrotropin - pharmacology
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Summary:THE demonstration that the sympathetic nervous system can have a direct effect on the thyroid 1 , and the increasing clinical use of adrenergic blocking agents in thyrotoxicosis have reawakened interest in the effects of catecholamines on the thyroid. We have therefore compared the effects of thyroid stimulating hormone (TSH) and isoproterenol, a β -adreneirgic stimulator, on the activation of protein kinase within the thyroid by cyclic AMP. We have also compared the inhibitory effects of the β -blocker propranolol, and the α -blocker phentolamine in this system. We found that isoproterenol is stimulatory at concentrations as low as 10 −8 M, and that l -propranolol, but not d -propranolol blocks this effect.
ISSN:0028-0836
1476-4687
DOI:10.1038/254347a0