Human placental transfer of AH8165

The human placental transfer of AH8165 (0times50times9 mg/kg) was studied in ten patients undergoing elective Caesarean section. There was no adverse effect on foetal movement attributable to placental transfer of the neuromuscular blocking drug. Bioassay of umbilical vein blood indicated that littl...

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Bibliographic Details
Published in:Anaesthesia 1975-01, Vol.30 (1), p.23-29
Main Authors: Blogg, C E, Simpson, B R, Tyers, M B, Martin, L E, Bell, J A
Format: Article
Language:English
Subjects:
Apgar Score
Azo Compounds - metabolism
Biological Assay
Endometrium - analysis
Female
Fetus - analysis
Humans
Hysterectomy
Imidazoles - metabolism
Liver - analysis
Maternal-Fetal Exchange
Muscles - analysis
Neuromuscular Blocking Agents - blood
Neuromuscular Blocking Agents - metabolism
Placenta - analysis
Placenta - metabolism
Pregnancy
Pyridinium Compounds - metabolism
Tritium - metabolism
Umbilical Cord
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Summary:The human placental transfer of AH8165 (0times50times9 mg/kg) was studied in ten patients undergoing elective Caesarean section. There was no adverse effect on foetal movement attributable to placental transfer of the neuromuscular blocking drug. Bioassay of umbilical vein blood indicated that little AH8165 crossed the placenta. Studies using 3HAH8165 in two patients undergoing termination hysterectomy demonstrated transfer of only minute amounts of radioactivity to the foetus.
ISSN:0003-2409
DOI:10.1111/j.1365-2044.1975.tb00790.x