Mucopolysaccharides and Thyroid Function

IN diseases with intense tissue disintegration, in agreement with reports in the literature 1,2 , the mucopolysaccharide (hexosamine)-level of blood was found to increase : thus in tuberculosis and in cancer it was found to increase from the normal level of 83 mgm. to 120–160 mgm. per 100 ml. In tub...

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Bibliographic Details
Published in:Nature (London) 1961-02, Vol.189 (4765), p.670-670
Main Authors: KROMPECHER, St, FORNET, B, BALOGH, G, OLÁH, E. H, LÁSZLÓ, M. B
Format: Article
Language:English
Subjects:
Glycosaminoglycans - blood
Humanities and Social Sciences
Humans
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
Thyroid Gland - physiology
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Summary:IN diseases with intense tissue disintegration, in agreement with reports in the literature 1,2 , the mucopolysaccharide (hexosamine)-level of blood was found to increase : thus in tuberculosis and in cancer it was found to increase from the normal level of 83 mgm. to 120–160 mgm. per 100 ml. In tuberculosis 3 and C 3 H mouse carcinoma 4 , the local formation of neutral mucopolysaccharides could be demonstrated. The neutral mucopolysaccharides—formed in the hypoxybiotic areas of the diseased tissues—are drained through the lymphatic vessels. They can be traced in the blood, and so the increase of the mucopolysaccharide content can be interpreted in terms of a pathological mechanism. It is known that, after healing, the mucopolysaccharide content returns to the normal level.
ISSN:0028-0836
1476-4687
DOI:10.1038/189670a0