Prereplicative Enzymic Changes in Regenerating Rat Liver

After partial hepatectomy in rats, the following changes in enzymic activities were observed in the remnant liver during the prereplicative period. In the initial period of the prereplicative process, soon after removal of part of the liver, ornithine decarboxylase [EC 4.1.1.17] and IMP dehydrogenas...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 1975-01, Vol.77 (3), p.641-645
Main Authors: EBINA, Yosuke, IWAI, Hajime, FUKUI, Noriko, OHTSUKA, Hidesato, MIURA, Yoshiaki
Format: Article
Language:English
Subjects:
Animals
Cyclic AMP - metabolism
Inosine Nucleotides
Ketone Oxidoreductases - metabolism
Liver - enzymology
Liver Regeneration
Male
Ornithine Decarboxylase - metabolism
Phosphoric Diester Hydrolases - metabolism
Rats
Thymidine Kinase - metabolism
Time Factors
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Summary:After partial hepatectomy in rats, the following changes in enzymic activities were observed in the remnant liver during the prereplicative period. In the initial period of the prereplicative process, soon after removal of part of the liver, ornithine decarboxylase [EC 4.1.1.17] and IMP dehydrogenase [EC 1.2.1.14] increase. Subsequently, for entry into the S period, thymidine kinase [EC 2.7.1.75] increases simultaneously with increase in the intracellular cyclic AMP level and decrease in its phosphodiesterase [EC 3.1.4.17].
ISSN:0021-924X
DOI:10.1093/oxfordjournals.jbchem.a130766