Thrombelastographic studies with a twenty-four-hour schedule for subcutaneous heparin. A comparison of its efficiency with prothrombin-depressing agents

In 55 patients 430 thrombelastographic studies after 305 heparin injections revealed that a more complete and more rapid reduction of the over-all coagulability of the blood is obtained by a subcutaneous injection of 40 per cent heparin once every 24 hours than that obtained with prothrombin-depress...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1961-11, Vol.24 (5), p.1206-1214
Main Authors: ELIOT, R S, VON KAULLA, K N, BLOUNT, Jr, S G
Format: Article
Language:English
Subjects:
Anticoagulants
Blood Coagulation - pharmacology
Coumarins - therapy
Heparin - therapy
Old Medline
Prothrombin
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Summary:In 55 patients 430 thrombelastographic studies after 305 heparin injections revealed that a more complete and more rapid reduction of the over-all coagulability of the blood is obtained by a subcutaneous injection of 40 per cent heparin once every 24 hours than that obtained with prothrombin-depressing agents. The individual dose, by the thrombelastographic technic, is between 3.5 and 4.5 mg./Kg. Further clinical studies are indicated with use of simple laboratory control technics, such as recalcification time.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.24.5.1206