Antidermatophytic Activity of 2‐Thiotetrahydro‐1,3,5‐thiadiazines and Isothiocyanates

Benzyl, furfuryl, tetrahydronaphthyl, α‐picolyl, and α‐homopicolyl derivatives of 2‐thiotetrahydro‐1,3,5‐thiadiazines were studied and found to be more active than β‐picolyl and pyridyl analogs on dermatophytes, including the more resistant Microsporum canis.

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1975-01, Vol.64 (1), p.164-165
Main Authors: Manohar, Vijaya, Murthy, S.V.K. Narasimha, Sirsi, M., Rao, G. Ramananda, Rao, P.L. Narasimha
Format: Article
Language:English
Subjects:
2-Thiotetrahydro-1
2‐Thiotetrahydro‐1,3,5‐thiadiazines—antidermatophytic activity
5-thiadiazines and isothiocyanates
5-thiadiazines-antidermatophytic activity
Antidermatophytic activity-2-thiotetrahydro-1
Antidermatophytic activity—2‐thiotetrahydro‐1,3,5‐thiadiazines and isothiocyanates
Antifungal Agents - pharmacology
Candida albicans - drug effects
Epidermophyton - drug effects
Griseofulvin - pharmacology
Isothiocyanates-antidermatophytic activity
Microsporum - drug effects
Thiadiazines - pharmacology
Thiazines - pharmacology
Thiocyanates - pharmacology
Trichophyton - drug effects
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Description
Summary:Benzyl, furfuryl, tetrahydronaphthyl, α‐picolyl, and α‐homopicolyl derivatives of 2‐thiotetrahydro‐1,3,5‐thiadiazines were studied and found to be more active than β‐picolyl and pyridyl analogs on dermatophytes, including the more resistant Microsporum canis.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600640140