The ultrastructure of the accessory sex organs of the male rat. 7. The effect of an anti-androgenic compound, SK and F 22340

The influence of a potent anti-androgenic compound, SK and F 22340, on the ultrastructure of the lateral and ventral prostate and the seminal vesicles of the rat has been studied. After treatment for 18 days there was macroscopic atrophy of the organs with decreased amount of secretory material. The...

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Bibliographic Details
Published in:Urological research 1975, Vol.2 (4), p.159-166
Main Authors: Tveter, K J, Dahl, E
Format: Article
Language:English
Subjects:
Androgen Antagonists
Animals
Atrophy
Cytoplasm - drug effects
Cytoplasmic Granules - drug effects
Endoplasmic Reticulum - drug effects
Epithelial Cells
Epithelium - drug effects
Golgi Apparatus - drug effects
Male
Microscopy, Electron
Prostate - drug effects
Prostate - ultrastructure
Rats
Ribosomes - drug effects
Seminal Vesicles - drug effects
Seminal Vesicles - ultrastructure
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Summary:The influence of a potent anti-androgenic compound, SK and F 22340, on the ultrastructure of the lateral and ventral prostate and the seminal vesicles of the rat has been studied. After treatment for 18 days there was macroscopic atrophy of the organs with decreased amount of secretory material. There was reduction of the height and width of the epithelial cells and loss of cytoplasm. The most distinct changes were found in the cytoplasm and comprised a quantitative reduction of the rough endoplasmic reticulum (RER) and of free ribosomes; the Golgi apparatus was reduced and the number of secretion granules were diminished. All the alterations observed are apparently similar to the changes caused by bilateral orchidectomy.
ISSN:0300-5623
1434-0879
DOI:10.1007/BF00257265