Synthesis and Evaluation of Antitumor Activity of 1‐[N, N‐Bis(2‐chloroethyl)sulfamoylphenyl]‐3,3‐dialkyltriazenes

• Published in: Journal of pharmaceutical sciences 1975-04, Vol.64 (4), p.698-699
• Main Authors: Lalezari, I., Afghahi, F.
• Format: Article
• Language: English
• Subjects: 1-p-dialkylsulfamoylphenyl; 3-dialkyltriazenes; and 1-p-[N; Animals; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - therapeutic use; Antitumor activity-six of 22 synthesized sulfamoylphenyltriazenes screened; Drug Evaluation, Preclinical; Leukemia L1210 - drug therapy; Mice; N-bis(2-chloroethyl)sulfamoylphenyl]-substituted 3; Nitrogen Mustard Compounds - chemical synthesis; Nitrogen Mustard Compounds - therapeutic use; six compounds screened for antitumor activity; six screened for antitumor activity; Sulfamoylphenyltriazenes-synthesis of 22 derivatives; Sulfamoylphenyltriazenes—synthesis of 22 derivatives, six screened for antitumor activity; Sulfanilamides - chemical synthesis; Sulfanilamides - therapeutic use; Triazene derivatives-synthesis of 22 1-p-sulfamoylphenyl; Triazene derivatives—synthesis of 22 1‐p‐sulfamoylphenyl‐, 1‐p‐dialkylsulfamoylphenyl‐, and 1‐p‐[N,N‐bis(2‐chloroethyl)sulfamoylphenyl]‐substituted 3,3‐dialkyltriazenes, six compounds screened for antitumor activity; Triazenes - chemical synthesis; Triazenes - therapeutic use
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600640430

Twenty‐two 1‐p‐sulfamoylphenyl‐3,3‐dialkyltriazenes, 1‐p‐dialkylsulfamoylphenyl‐3,3‐dialkyltriazenes, and 1‐p‐[N,N ‐ bis(2 ‐ chloroethyl)sulfamoylphenyl] ‐ 3,3 ‐ dialkyltriazenes were synthesized from their corresponding amines. Six of the compounds tested were devoid of antitumor activity.