Biological Disposition of Apomorphine IV. Isolation and Characterization of “Bound” Apomorphine

“Bound” apomorphine, the major metabolic product of apomorphine, has been isolated from the urine of rabbits by a series of ion exchange procedures, fractionated by paper chromatography, and identified by enzymatic hydrolysis and various color tests. It has been found to consist of two metabolites w...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1961-10, Vol.50 (10), p.840-842
Main Authors: Kaul, P.N., Brochmann-Hanssen, E., Way, E. Leong
Format: Article
Language:English
Subjects:
Apomorphine - chemistry
Old Medline
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Summary:“Bound” apomorphine, the major metabolic product of apomorphine, has been isolated from the urine of rabbits by a series of ion exchange procedures, fractionated by paper chromatography, and identified by enzymatic hydrolysis and various color tests. It has been found to consist of two metabolites which, based on electronic absorption and stereochemical consideration, are designated as apomorphine 3,O-sorption and 4,O-β-glucuronides, respectively.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600501008