Aldosterone-induced membrane phospholipid fatty acid metabolism in the toad urinary bladder

Aldosterone action in the isolated toad urinary bladder has been studied by incubation of the tissue with several specifically labeled lipogenic precursors. Within 30 min after hormone addition phospholipid synthesis is stimulated; the metabolism of oleic acid is particularly enhanced. Additionally,...

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Bibliographic Details
Published in:Biochemistry (Easton) 1975-07, Vol.14 (13), p.2803-2809
Main Authors: Goodman, David B. P, Wong, Mitzi, Rasmussen, Howard
Format: Article
Language:English
Subjects:
Acetates - metabolism
Acetyl Coenzyme A - metabolism
Aldosterone - pharmacology
Animals
Bufo marinus
Cell Membrane - drug effects
Cell Membrane - metabolism
Chromatography, Gas
Fatty Acids - metabolism
Female
In Vitro Techniques
Oleic Acids - metabolism
Oxidation-Reduction
Palmitates - metabolism
Phospholipases - metabolism
Phospholipids - metabolism
Stimulation, Chemical
Time Factors
Urinary Bladder - drug effects
Urinary Bladder - metabolism
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Summary:Aldosterone action in the isolated toad urinary bladder has been studied by incubation of the tissue with several specifically labeled lipogenic precursors. Within 30 min after hormone addition phospholipid synthesis is stimulated; the metabolism of oleic acid is particularly enhanced. Additionally, during this time interval a phospholipid deacylation-reacylation cycle is stimulated by aldosterone.
ISSN:0006-2960
1520-4995
DOI:10.1021/bi00684a003