Studies of the rabbit antibodies which sensitize red blood cells for agglutination by rheumatoid factors

The high and low molecular weight antibodies of rabbit antisheep red cell serum were separated by electrophoresis, density gradient ultracentrifugation, and DEAE chromatography. It was demonstrated that only antibodies of the low molecular weight class were able to sensitize cells in subagglutinatin...

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Bibliographic Details
Published in:Arthritis and rheumatism 1961-10, Vol.4 (5), p.449-462
Main Authors: Rockey, John H., Kunkel, Henry G.
Format: Article
Language:English
Subjects:
Agglutination
Animals
Antibodies
Arthritis
Arthritis, Rheumatoid - immunology
Erythrocyte Count
Erythrocytes
Hemagglutination
Old Medline
Rabbits
Rheumatoid Factor
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Summary:The high and low molecular weight antibodies of rabbit antisheep red cell serum were separated by electrophoresis, density gradient ultracentrifugation, and DEAE chromatography. It was demonstrated that only antibodies of the low molecular weight class were able to sensitize cells in subagglutinating titer for agglutination by rheumatoid factors. High molecular weight antibodies lacked this capacity. The roles of incomplete rabbit antirabbit red cell and antisheep red cell antibodies in sensitization is discussed. Le anticorpores a alte e a basse pesos molecular in sero de conilio anti erythrocytos ovin esseva separate per electrophorese, ultracentrifugation a gradiente de densitate, e chromatographia DEAE. Esseva demonstrate que solmente anticorpores del classe a basse peso molecular esseva capace a sensibilisar cellulas in titro subagglutinante pro le agglutination per factores rheumatoide. Anticorpores a alte peso molecular non habeva iste capacitate. Es discutite le rolo de incomplete anticorpore de conilio anti erythrocytos de conilio e anti erythrocytos de ove in le mechanismo del sensibilisation.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780040502