Dissociation of Thrombosthenin into Two Components comparable with Actin and Myosin

BLOOD platelets are capable of inducing the retraction of blood clots as well as of undergoing morphological and structural changes termed ‘viscous metamorphosis’. Both phenomena are manifestations of the same basic processes, and they are interlinked with the important functions of platelets in the...

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Bibliographic Details
Published in:Nature (London) 1962-02, Vol.193 (4817), p.777-778
Main Authors: BETTEX-GALLAND, M, PORTZEHL, H, LÜSCHER, E. F
Format: Article
Language:English
Subjects:
Actins
Blood Platelets - chemistry
Blood Proteins - chemistry
Humanities and Social Sciences
Humans
letter
multidisciplinary
Myosins
Old Medline
Proteins
Science
Science (multidisciplinary)
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Summary:BLOOD platelets are capable of inducing the retraction of blood clots as well as of undergoing morphological and structural changes termed ‘viscous metamorphosis’. Both phenomena are manifestations of the same basic processes, and they are interlinked with the important functions of platelets in the hæmostatic mechanism. In 1959 we reported the isolation of a contractile protein from human blood platelets 1 . This material, afterwards termed ‘thrombosthenin’, accounts for 15 per cent of the platelet proteins, and most likely plays an important part in the functions of the platelet 2 .
ISSN:0028-0836
1476-4687
DOI:10.1038/193777a0