THE INFLUENCE OF CERTAIN GANGLIONIC BLOCKING AGENTS ON NEUROMUSCULAR TRANSMISSION

Experiments to investigate the action of hexa-methonium, trimetaphan and phenactropinium on neuromuscular transmission in intact, anaesthetized dogs are described. Blood pressure was maintained throughout by infusion of noradrena-line so that the effects of hypotension should not obscure the results...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1962-06, Vol.34 (6), p.357-362
Main Authors: DEACOCK, A. R. DE C., HARGROVE, R.L.
Format: Article
Language:English
Subjects:
Autonomic Agents - pharmacology
Ganglionic Blockers
Hexamethonium Compounds - pharmacology
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Summary:Experiments to investigate the action of hexa-methonium, trimetaphan and phenactropinium on neuromuscular transmission in intact, anaesthetized dogs are described. Blood pressure was maintained throughout by infusion of noradrena-line so that the effects of hypotension should not obscure the results. All three drugs under investigation produced complete neuromuscular block. The absence of initial muscle fasciculation and the response to neostigmine indicated that the block was of non-depolarizing type. Trimetaphan and phenactro-pinium were found to depress plasma cholines-terase activity. Quantitative evaluation of the results suggests that clinically significant depression of neuro-muscular transmission may be produced by trimetaphan and phenactropinium, but not by hexamethonium.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/34.6.357