Non-antiviral activities of interferon are not controlled by chromosome 21

USING mouse–human cell hybrids, Tan et al. 1 assigned the gene(s) for the expression of the antiviral state induced by human (leukocyte) interferon to chromosome 21; furthermore, human skin fibroblasts trisomic for chromosome 21 proved more sensitive to the antiviral activity of human (leukocyte) in...

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Bibliographic Details
Published in:Nature (London) 1975-07, Vol.256 (5513), p.132-134
Main Authors: CLERCQ, ERIK DE, EDY, VICTOR G, CASSIMAN, JEAN-JACQUES
Format: Article
Language:English
Subjects:
Cell Line
Cell Survival
Chromosome Aberrations
Chromosome Mapping
Chromosomes, Human, 21-22 and Y
Fibroblasts - drug effects
Fibroblasts - metabolism
Humanities and Social Sciences
Humans
Interferons - metabolism
Interferons - pharmacology
letter
Leukocytes
multidisciplinary
Poly I-C - pharmacology
Polyploidy
Science
Science (multidisciplinary)
Viral Interference
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Summary:USING mouse–human cell hybrids, Tan et al. 1 assigned the gene(s) for the expression of the antiviral state induced by human (leukocyte) interferon to chromosome 21; furthermore, human skin fibroblasts trisomic for chromosome 21 proved more sensitive to the antiviral activity of human (leukocyte) interferon than normal diploid fibroblasts or trisomic 18 or 13 fibroblasts 2,3 . Since the non-antiviral and antiviral activities of interferon remain inseparably linked through approximately a million-fold purification (ref. 4 and references cited therein), the question may be raised whether these various activities of interferon are accounted for by the same mechanisms and whether the expression of the non-antiviral activity of (human) interferon is also controlled by chromosome 21.
ISSN:0028-0836
1476-4687
DOI:10.1038/256132a0