Action of 1,1,Dichloro-2-p-chlorophenyl-2-o-chlorophenylethane on Dog Adrenal Cortex

A single intravenous injection of op$^{\prime}$ DDD (1,1,dichloro-2-p-chlorophenyl-2-o-chlorophenylethane) has an acute effect on the adrenal cortex of the dog. Within 2 hours after intravenous injection of the drug, there is a decrease in the in vitro response of the adrenal cortex to stimulation b...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1962-04, Vol.136 (3510), p.47-47
Main Authors: Cazorla, Alberto, Moncloa, Federico
Format: Article
Language:English
Subjects:
Adrenal cortex
Adrenal Cortex - pharmacology
Adrenal Cortex Hormones
Adrenocorticotropic Hormone
Animals
DDT - analogs & derivatives
Dehydrogenases
Dogs
Flasks
Glucosephosphate Dehydrogenase
Intravenous injections
Old Medline
Oxidation-Reduction
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Summary:A single intravenous injection of op$^{\prime}$ DDD (1,1,dichloro-2-p-chlorophenyl-2-o-chlorophenylethane) has an acute effect on the adrenal cortex of the dog. Within 2 hours after intravenous injection of the drug, there is a decrease in the in vitro response of the adrenal cortex to stimulation by adrenocorticotrophic hormone and an inhibition of glucose-6-phosphate dehydrogenase activity. The inhibition of glucose-6-phosphate dehydrogenase activity might explain the effect of op$^{\prime}$ DDD on corticosteroid production.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.136.3510.47