Effects of Intraventricularly Injected Anti-N. Caudatus Antibody on the Electrical Activity of the Cat Brain

IT is well known that anti-tissue antibodies, when injected into an animal of the donor species, may exhibit the selective affinity for the homologous organ and produce certain modifications in its morphological and functional state 1 . The damaging effects of anti-tissue antibodies have been demons...

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Bibliographic Details
Published in:Nature (London) 1961-11, Vol.192 (4803), p.665-666
Main Authors: MIHAILOVIC, L, JANKOVIC, B D
Format: Article
Language:English
Subjects:
Animals
Antibodies
Basal Ganglia
Brain - physiology
Cats
Caudate Nucleus
Ganglia
Humanities and Social Sciences
Immunoglobulins
letter
multidisciplinary
Old Medline
Science
Science (multidisciplinary)
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Summary:IT is well known that anti-tissue antibodies, when injected into an animal of the donor species, may exhibit the selective affinity for the homologous organ and produce certain modifications in its morphological and functional state 1 . The damaging effects of anti-tissue antibodies have been demonstrated in different organs 2 . However, no information could be found in the literature available concerning the physiopathological events associated with an in vivo collision between anti-brain antibodies and the corresponding nervous tissue. Bearing in mind the high complexity of morphological and functional organization of the brain, a series of immuno-electro-physiological experiments has been undertaken to investigate the possible differential reactivity of various cerebral structures when exposed to the action of different brain region anti-sera. The present communication, as a part of these investigations, is a preliminary report concerning only some of the effects of intraventricularly administered anti-n. caudatus antibody on the electrical activity of various parts of the cat brain.
ISSN:0028-0836
1476-4687
DOI:10.1038/192665a0