Conditions for Stable Polymorphism at an Autosomal Locus

IT is frequently stated that, apart from the effects of mutation and migration, two autosomal allelomorphs can only be in stable equilibrium if the heterozygote is fitter than either homozygote, or if the fitness of genotypes varies with their frequency in the population. This is not true.

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Bibliographic Details
Published in:Nature (London) 1962-03, Vol.193 (4820), p.1108-1108
Main Author: HALDANE, J. B. S
Format: Article
Language:English
Subjects:
Genetics
Humanities and Social Sciences
letter
multidisciplinary
Old Medline
Polymorphism, Genetic
Science
Science (multidisciplinary)
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Description
Summary:IT is frequently stated that, apart from the effects of mutation and migration, two autosomal allelomorphs can only be in stable equilibrium if the heterozygote is fitter than either homozygote, or if the fitness of genotypes varies with their frequency in the population. This is not true.
ISSN:0028-0836
1476-4687
DOI:10.1038/1931108a0