Hypo-.beta.-lipoproteinemic agents. 1. Bicyclo[2.2.2]octyloxyaniline and its derivatives

A new assay for agents which normalize beta-lipoproteins in cholesterol-cholic acid fed rats is described. Both lowering of serum cholesterol and of serum heparin precipitable lipoproteins (HPL) were measured at the end of the treatment period. Compounds which shifted the ratio of the decrease in fa...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1975-11, Vol.18 (11), p.1065-1070
Main Authors: Day, Charles E, Schurr, Paul E, Emmert, D. Edward, TenBrink, Ruth E, Lednicer, Daniel
Format: Article
Language:English
Subjects:
Aniline Compounds - chemical synthesis
Aniline Compounds - pharmacology
Animals
Bridged Bicyclo Compounds - chemical synthesis
Bridged Bicyclo Compounds - pharmacology
Bridged-Ring Compounds - chemical synthesis
Cholesterol - blood
Depression, Chemical
Hypolipidemic Agents - chemical synthesis
Hypolipidemic Agents - pharmacology
Lipoproteins, LDL - blood
Rats
Triglycerides - blood
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Summary:A new assay for agents which normalize beta-lipoproteins in cholesterol-cholic acid fed rats is described. Both lowering of serum cholesterol and of serum heparin precipitable lipoproteins (HPL) were measured at the end of the treatment period. Compounds which shifted the ratio of the decrease in favor of HPL are considered hypo-beta-lipoproteinemic. p-(1-Bicyclo[2.2.2]octyloxy)aniline and several of its derivatives proved active in this assay. The synthesis of these compounds is described.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00245a004