Electron microscopic observations on extraneuronal lipofuscin in the monkey brain

Ultrastructure of osmiophilic bodies identified as lipofuscin granules occurring at extraneuronal sites in the brain tissue of both young and old monkeys was studied. The present work revealed that lipofuscin granules were detected normally in the neuroglia cells, phagocytic cells and pericytes surr...

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Bibliographic Details
Published in:Cell and tissue research 1975-08, Vol.161 (4), p.555-565
Main Authors: El-Ghazzawi, E F, Malaty, H A
Format: Article
Language:English
Subjects:
Aging
Animals
Capillaries - analysis
Cytoplasmic Granules - ultrastructure
Endothelium - analysis
Haplorhini
Hypothalamus - analysis
Hypothalamus - ultrastructure
Lipofuscin - analysis
Lipofuscin - metabolism
Macaca fascicularis
Male
Nerve Tissue - analysis
Nerve Tissue - ultrastructure
Neuroglia - analysis
Phagocytes - analysis
Pigments, Biological - analysis
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Summary:Ultrastructure of osmiophilic bodies identified as lipofuscin granules occurring at extraneuronal sites in the brain tissue of both young and old monkeys was studied. The present work revealed that lipofuscin granules were detected normally in the neuroglia cells, phagocytic cells and pericytes surrounding the blood capillaries, as well as in the capillary endothelium. However, their presence in these sites was more marked in young animals. The findings presented in this report are strongly suggestive of the normal removal of lipofuscin from the nerve cells to the capillary endothelium, and suggest further that the phagocytic cells as well as the glia cells participate in this removal mechanism. Being a more active process during youth, few lipofuscin granules are present in neurones from young animals. Failure of the removal mechanism due to diminished activity of the participating cells with ageing, is probably the cause of lipofuscin accumulation in senescent neurones.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00224144