Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes

THE platelet plasma membrane contains several proteins of different molecular weights. Three of these proteins stain for carbohydrate with periodic acid–Schiff reagent and have been termed glycoproteins I, II and III (molecular weights 150,000, 124,000 and 106,000, respectively) 1,2 . It has been su...

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Bibliographic Details
Published in:Nature (London) 1975-10, Vol.257 (5527), p.599-600
Main Authors: PHILLIPS, DAVID R, JENKINS, C. S. P, LÜSCHER, E. F, LARRIEU, MARIE-JOSE
Format: Article
Language:English
Subjects:
Blood Platelets - analysis
Blood Platelets - ultrastructure
Cell Membrane - analysis
Glycoproteins - blood
Humanities and Social Sciences
Humans
letter
multidisciplinary
Purpura, Thrombocytopenic - blood
Purpura, Thrombocytopenic - genetics
Science
Science (multidisciplinary)
Syndrome
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Summary:THE platelet plasma membrane contains several proteins of different molecular weights. Three of these proteins stain for carbohydrate with periodic acid–Schiff reagent and have been termed glycoproteins I, II and III (molecular weights 150,000, 124,000 and 106,000, respectively) 1,2 . It has been suggested that the bleeding tendency observed in Glanz-mann's thrombasthenia results from abnormalities of the platelet membrane 3–6 . Nurden and Caen 7 showed that glycoprotein II was absent in a crude membrane fraction isolated from thrombasthenic platelets. We have now investigated the surface composition of thrombasthenic membranes by the lactoperoxidase iodination technique 2 and found a low concentration of glycoprotein II, and other molecular differences.
ISSN:0028-0836
1476-4687
DOI:10.1038/257599a0