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Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes
THE platelet plasma membrane contains several proteins of different molecular weights. Three of these proteins stain for carbohydrate with periodic acid–Schiff reagent and have been termed glycoproteins I, II and III (molecular weights 150,000, 124,000 and 106,000, respectively) 1,2 . It has been su...
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| Published in: | Nature (London) 1975-10, Vol.257 (5527), p.599-600 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c335t-c5e2a467e03b7ae326a17bdf97e9b3188ab8a22e3b6343b239c15ddf29d74b053 |
| container_end_page | 600 |
| container_issue | 5527 |
| container_start_page | 599 |
| container_title | Nature (London) |
| container_volume | 257 |
| creator | PHILLIPS, DAVID R JENKINS, C. S. P LÜSCHER, E. F LARRIEU, MARIE-JOSE |
| description | THE platelet plasma membrane contains several proteins of different molecular weights. Three of these proteins stain for carbohydrate with periodic acid–Schiff reagent and have been termed glycoproteins I, II and III (molecular weights 150,000, 124,000 and 106,000, respectively)
1,2
. It has been suggested that the bleeding tendency observed in Glanz-mann's thrombasthenia results from abnormalities of the platelet membrane
3–6
. Nurden and Caen
7
showed that glycoprotein II was absent in a crude membrane fraction isolated from thrombasthenic platelets. We have now investigated the surface composition of thrombasthenic membranes by the lactoperoxidase iodination technique
2
and found a low concentration of glycoprotein II, and other molecular differences. |
| doi_str_mv | 10.1038/257599a0 |
| format | article |
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1,2
. It has been suggested that the bleeding tendency observed in Glanz-mann's thrombasthenia results from abnormalities of the platelet membrane
3–6
. Nurden and Caen
7
showed that glycoprotein II was absent in a crude membrane fraction isolated from thrombasthenic platelets. We have now investigated the surface composition of thrombasthenic membranes by the lactoperoxidase iodination technique
2
and found a low concentration of glycoprotein II, and other molecular differences.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/257599a0</identifier><identifier>PMID: 1172605</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Blood Platelets - analysis ; Blood Platelets - ultrastructure ; Cell Membrane - analysis ; Glycoproteins - blood ; Humanities and Social Sciences ; Humans ; letter ; multidisciplinary ; Purpura, Thrombocytopenic - blood ; Purpura, Thrombocytopenic - genetics ; Science ; Science (multidisciplinary) ; Syndrome</subject><ispartof>Nature (London), 1975-10, Vol.257 (5527), p.599-600</ispartof><rights>Springer Nature Limited 1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-c5e2a467e03b7ae326a17bdf97e9b3188ab8a22e3b6343b239c15ddf29d74b053</citedby><cites>FETCH-LOGICAL-c335t-c5e2a467e03b7ae326a17bdf97e9b3188ab8a22e3b6343b239c15ddf29d74b053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1172605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PHILLIPS, DAVID R</creatorcontrib><creatorcontrib>JENKINS, C. S. P</creatorcontrib><creatorcontrib>LÜSCHER, E. F</creatorcontrib><creatorcontrib>LARRIEU, MARIE-JOSE</creatorcontrib><title>Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>THE platelet plasma membrane contains several proteins of different molecular weights. Three of these proteins stain for carbohydrate with periodic acid–Schiff reagent and have been termed glycoproteins I, II and III (molecular weights 150,000, 124,000 and 106,000, respectively)
1,2
. It has been suggested that the bleeding tendency observed in Glanz-mann's thrombasthenia results from abnormalities of the platelet membrane
3–6
. Nurden and Caen
7
showed that glycoprotein II was absent in a crude membrane fraction isolated from thrombasthenic platelets. We have now investigated the surface composition of thrombasthenic membranes by the lactoperoxidase iodination technique
2
and found a low concentration of glycoprotein II, and other molecular differences.</description><subject>Blood Platelets - analysis</subject><subject>Blood Platelets - ultrastructure</subject><subject>Cell Membrane - analysis</subject><subject>Glycoproteins - blood</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Purpura, Thrombocytopenic - blood</subject><subject>Purpura, Thrombocytopenic - genetics</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Syndrome</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><recordid>eNptkE1LxDAQhoMo67oK_gGlJ9FDNR9Nkx5l8QtWvOhRSpJO3S5tuiYp6L83S9f14mkG3oeHmRehU4KvCWbyhnLBi0LhPTQlmcjTLJdiH00xpjLFkuWH6Mj7FcaYE5FN0IQQQXPMp-j9uW_BDK1ySdXUNTiwBnzS1wl8rXsPVeIHVysDydr1ARobM5uEpes7rXxYgm1Msm5VgBbCZvGdSjrotFMW_DE6qFXr4WQ7Z-jt_u51_pguXh6e5reL1DDGQ2o4UJXlAjDTQgGjuSJCV3UhoNCMSKm0VJQC0znLmKasMIRXVU2LSmQaczZDF6M3Hvk5gA9l13gDbRuP6AdfSoYJLySL4OUIGtd776Au167plPsuCS43TZa_TUb0bOscdAfVHzhWF_OrMfcxsR_gylU_OBvf_M91PrJWhcHBzrUDfgD3Ioa3</recordid><startdate>19751016</startdate><enddate>19751016</enddate><creator>PHILLIPS, DAVID R</creator><creator>JENKINS, C. S. P</creator><creator>LÜSCHER, E. F</creator><creator>LARRIEU, MARIE-JOSE</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19751016</creationdate><title>Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes</title><author>PHILLIPS, DAVID R ; JENKINS, C. S. P ; LÜSCHER, E. F ; LARRIEU, MARIE-JOSE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-c5e2a467e03b7ae326a17bdf97e9b3188ab8a22e3b6343b239c15ddf29d74b053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Blood Platelets - analysis</topic><topic>Blood Platelets - ultrastructure</topic><topic>Cell Membrane - analysis</topic><topic>Glycoproteins - blood</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Purpura, Thrombocytopenic - blood</topic><topic>Purpura, Thrombocytopenic - genetics</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PHILLIPS, DAVID R</creatorcontrib><creatorcontrib>JENKINS, C. S. P</creatorcontrib><creatorcontrib>LÜSCHER, E. F</creatorcontrib><creatorcontrib>LARRIEU, MARIE-JOSE</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PHILLIPS, DAVID R</au><au>JENKINS, C. S. P</au><au>LÜSCHER, E. F</au><au>LARRIEU, MARIE-JOSE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1975-10-16</date><risdate>1975</risdate><volume>257</volume><issue>5527</issue><spage>599</spage><epage>600</epage><pages>599-600</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>THE platelet plasma membrane contains several proteins of different molecular weights. Three of these proteins stain for carbohydrate with periodic acid–Schiff reagent and have been termed glycoproteins I, II and III (molecular weights 150,000, 124,000 and 106,000, respectively)
1,2
. It has been suggested that the bleeding tendency observed in Glanz-mann's thrombasthenia results from abnormalities of the platelet membrane
3–6
. Nurden and Caen
7
showed that glycoprotein II was absent in a crude membrane fraction isolated from thrombasthenic platelets. We have now investigated the surface composition of thrombasthenic membranes by the lactoperoxidase iodination technique
2
and found a low concentration of glycoprotein II, and other molecular differences.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1172605</pmid><doi>10.1038/257599a0</doi><tpages>2</tpages></addata></record> |
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| ispartof | Nature (London), 1975-10, Vol.257 (5527), p.599-600 |
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| language | eng |
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| source | Springer Nature - Connect here FIRST to enable access |
| subjects | Blood Platelets - analysis Blood Platelets - ultrastructure Cell Membrane - analysis Glycoproteins - blood Humanities and Social Sciences Humans letter multidisciplinary Purpura, Thrombocytopenic - blood Purpura, Thrombocytopenic - genetics Science Science (multidisciplinary) Syndrome |
| title | Molecular differences of exposed surface proteins on thrombasthenic platelet plasma membranes |
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