Sex difference in ontogenesis of circadian adrenocortical rhythm in cortisone-primed rats

THE hormonal milieu in the neonatal period has profound influences on the morphological, biochemical and functional development of the brain 1,2 . Krieger reported that the administration of corticosteroid (dexamethasone or hydrocortisone) to 2–4-d-old rats suppressed the circadian rhythm of plasma...

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Bibliographic Details
Published in:Nature (London) 1975-08, Vol.256 (5518), p.590-592
Main Authors: MIYABO, SUSUMU, HISADA, TOMOICHIRO
Format: Article
Language:English
Subjects:
Age Factors
Animals
Animals, Newborn
Circadian Rhythm - drug effects
Corticosterone - blood
Cortisone - pharmacology
Ethers - pharmacology
Female
Humanities and Social Sciences
letter
Male
multidisciplinary
Rats
Science
Science (multidisciplinary)
Sex Characteristics
Stress, Physiological - physiopathology
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Summary:THE hormonal milieu in the neonatal period has profound influences on the morphological, biochemical and functional development of the brain 1,2 . Krieger reported that the administration of corticosteroid (dexamethasone or hydrocortisone) to 2–4-d-old rats suppressed the circadian rhythm of plasma corticosterone at 30 d of age 3 , whereas treatment at 12–14 d of age did not affect the rhythmicity. We have investigated whether the suppression of corticosterone rhythm results in its permanent derangement throughout adult life or merely indicates its delayed appearance. After this paper was submitted, Krieger published the results of a similar study 4 .
ISSN:0028-0836
1476-4687
DOI:10.1038/256590a0