Antitumor Agents XV: Deoxyelephantopin, an Antitumor Principle from Elephantopus carolinianus Willd

The active principle responsible for the significant inhibitory activity against the Walker 256 carcinosarcoma (ascites) in rats, isolated from the chloroform extract of the whole plant of Elephantopus carolinianus Willd., was characterized as deoxyelephantopin, a sesquiterpene lactone.

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1975-09, Vol.64 (9), p.1572-1573
Main Authors: Wolo, MacArthur T., Cowherd, Carole M., Lee, Kuo‐Hsiung
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - therapeutic use
antitumor activity
Antitumor agents
Antitumor agents, potential—deoxyelephantopin, major constituent of Elephantopus carolinianus Willd
Carcinoma 256, Walker - drug therapy
Deoxyelephantopin-isolation from Elephantopus carolinianus Willd
Deoxyelephantopin—isolation from Elephantopus carolinianus Willd., structure identification, antitumor activity
Elephantopus carolinianus Willd.-isolation and structure identification of deoxyelephantopin
Elephantopus carolinianus Willd.—isolation and structure identification of deoxyelephantopin, antitumor activity
major constituent of Elephantopus carolinianus Willd
Oxidation-Reduction
Plant Extracts - therapeutic use
potential-deoxyelephantopin
Rats
structure identification
Structure-activity relationships-sesquiterpene lactones (deoxyelephantopin) as antitumor agents
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Description
Summary:The active principle responsible for the significant inhibitory activity against the Walker 256 carcinosarcoma (ascites) in rats, isolated from the chloroform extract of the whole plant of Elephantopus carolinianus Willd., was characterized as deoxyelephantopin, a sesquiterpene lactone.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600640938