Changes in renal hemodynamics and sodium excretion during saline infusion in lambs

The renal response to a progressive isotonic extracellular volume (ECV) expansion was studied in 13 lambs of two age groups (5–28 days and 48–57 days). Changes in renal hemodynamics induced by the ECV expansion were followed. Intraenal blood flow was determined by the microsphere method. For determi...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1975-08, Vol.94 (4), p.442-450
Main Authors: Aperia, A, Broberger, O, Herin, P
Format: Article
Language:English
Subjects:
age
Age Factors
animal science
Animals
Blood Proteins - metabolism
Cardiac Output - drug effects
Extracellular Space - drug effects
Female
filtration fraction
Glomerular Filtration Rate
Hematocrit
Infusions, Parenteral
Isotonic volume expansion
Kidney - blood supply
Kidney - physiology
Kidney Cortex - blood supply
livestock
Male
microsphere method
Natriuresis
Regional Blood Flow
renal hemodynamics
Sheep - physiology
Sodium - pharmacology
Sodium Chloride - administration & dosage
sodium excretion
Stimulation, Chemical
Time Factors
zoology
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Summary:The renal response to a progressive isotonic extracellular volume (ECV) expansion was studied in 13 lambs of two age groups (5–28 days and 48–57 days). Changes in renal hemodynamics induced by the ECV expansion were followed. Intraenal blood flow was determined by the microsphere method. For determination of the glomerular filtration rate (GFR) standard clearance techniques were used. Recordings were made during control conditions and when normal saline had been infused in amounts up to 4.5% of the body weight. During the infusion there was an increase in sodium excretion both in absolute values and in relationship to GFR. The increase was, however, much less pronounced in the younger lambs. The GFR did not change significantly during saline infusion. The cortical blood flow increased only in the older lambs. As a consequence the quotient between GFR and cortical blood flow decreased in the older lambs. The possibility of a causal relationship between the fall in filtration fraction so obtained and the more pronounced natriuretic response in the older lambs is discussed. The inner to outer cortical blood flow ratio increased more in the younger lambs during saline infusion. The functional significance of an age related blood flow redistribution is, however, not clear.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1975.tb05903.x