SEPTAMYCIN, A POLYETHER ANTIBIOTIC: TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION

Septamycin is a metal complexing polyether antibiotic produced by a strain of Streptomyces hygroscopicus NRRL 5678. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C48H81NaO16. The crystal structure and absolute configuration were established by X-ray analysis of the p-bromoph...

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Bibliographic Details
Published in:Journal of antibiotics 1975, Vol.28(11), pp.854-859
Main Authors: KELLER-JUSLÉN, CAMILLA, KING, HAMILTON D., KIS, ZOLTAN L., WARTBURG, ALBERT VON
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - classification
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Chemical Phenomena
Chemistry
Chickens
Coccidiosis - drug therapy
Dogs
Ethers - classification
Ethers - isolation & purification
Ethers - pharmacology
Newcastle disease virus - drug effects
Poultry Diseases - drug therapy
Rats
Simplexvirus - drug effects
Streptomyces - metabolism
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Description
Summary:Septamycin is a metal complexing polyether antibiotic produced by a strain of Streptomyces hygroscopicus NRRL 5678. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C48H81NaO16. The crystal structure and absolute configuration were established by X-ray analysis of the p-bromophenacyl derivative. Septamycin has a thirty-carbon backbone and contains seven heterocyclic rings. Supported by direct comparison septamycin proved to be identical with antibiotic A28695 A isolated from Streptomyces albus NRRL 3883. The metabolite is active against gram-positive
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.28.854