Effect of Ethionine on the Transport of Cholesterol-4-C14 in Rat Lipoproteins

Ethionine administration to female rats resulted in a significant increase in the radioactivity of the chylomicron fraction after ingestion of cholesterol‐4‐C14. On the other hand, ethionine administration resulted in a marked decrease in the incorporation of radioactivity into the α1, lipoprotein f...

Full description

Saved in:
Bibliographic Details
Published in:Acta physiologica Scandinavica 1962-10, Vol.56 (2), p.157-161
Main Authors: Karvinen, Esko, Miettinen, Matti
Format: Article
Language:English
Subjects:
Animals
Biological Transport
Cholesterol - blood
Chylomicrons
Ethionine
Lipoproteins
Liver Diseases
Old Medline
Rats
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ethionine administration to female rats resulted in a significant increase in the radioactivity of the chylomicron fraction after ingestion of cholesterol‐4‐C14. On the other hand, ethionine administration resulted in a marked decrease in the incorporation of radioactivity into the α1, lipoprotein fraction after ingestion of cholesterol‐4‐C14. In the normal rat 70 % of the radioactivity contained in the serum was found in the lipid of α1, lipoprotein whereas in the ethionine rats a trace of radioactivity only was found in the α2, fraction. There were no significant differences in the activities of the α2 and β lipoprotein fractions between the ethionine and control rats. It is concluded that liver damage by ethionine resulted in a specific inhibition of the formation of α1 lipoprotein.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1962.tb02493.x