Effect of Ethionine on the Transport of Cholesterol-4-C14 in Rat Lipoproteins

Ethionine administration to female rats resulted in a significant increase in the radioactivity of the chylomicron fraction after ingestion of cholesterol‐4‐C14. On the other hand, ethionine administration resulted in a marked decrease in the incorporation of radioactivity into the α1, lipoprotein f...

Full description

Saved in:
Bibliographic Details
Published in:Acta physiologica Scandinavica 1962-10, Vol.56 (2), p.157-161
Main Authors: Karvinen, Esko, Miettinen, Matti
Format: Article
Language:English
Subjects:
Animals
Biological Transport
Cholesterol - blood
Chylomicrons
Ethionine
Lipoproteins
Liver Diseases
Old Medline
Rats
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 161
container_issue 2
container_start_page 157
container_title Acta physiologica Scandinavica
container_volume 56
creator Karvinen, Esko
Miettinen, Matti
description Ethionine administration to female rats resulted in a significant increase in the radioactivity of the chylomicron fraction after ingestion of cholesterol‐4‐C14. On the other hand, ethionine administration resulted in a marked decrease in the incorporation of radioactivity into the α1, lipoprotein fraction after ingestion of cholesterol‐4‐C14. In the normal rat 70 % of the radioactivity contained in the serum was found in the lipid of α1, lipoprotein whereas in the ethionine rats a trace of radioactivity only was found in the α2, fraction. There were no significant differences in the activities of the α2 and β lipoprotein fractions between the ethionine and control rats. It is concluded that liver damage by ethionine resulted in a specific inhibition of the formation of α1 lipoprotein.
doi_str_mv 10.1111/j.1748-1716.1962.tb02493.x
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_83104997</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83104997</sourcerecordid><originalsourceid>FETCH-LOGICAL-i2337-c1412add7575bacbdc8c564c3144706a13c67b71f352b8b0082875db19cfd8d63</originalsourceid><addsrcrecordid>eNpFkMtOwzAQRS0EgvL4BRSxYOfgsR07WaGqlIIoD0F57CzHcVSXNC5JKsrfk9ACsxmN5s69o4PQCZAQ2jqbhSB5jEGCCCERNGxSQnnCwtUW6gETEaYE3rZRjxACWEhJ99B-Xc_akcWU7qI9YO2ZoKyHbod5bk0T-DwYNlPnS1fawJdBM7XBpNJlvfDVz3Yw9YWtG1v5AnM8AB64MnjUTTB2C7-ofGNdWR-inVwXtT3a9AP0fDmcDK7w-H50PeiPsaOMSWyAA9VZJiMZpdqkmYlNJLhhwLkkQgMzQqYSchbRNE4JiWksoyyFxORZnAl2gE7Xvm3wx7J9S81dbWxR6NL6Za1iBoQniWyFxxvhMp3bTC0qN9fVl_oF0ArO14JPV9iv_z1RHWo1Ux1q1aFWHWq1Qa1Wqv9w1Yeoi8BrB9fSWf056OpdCclkpF7vRuqJTe5uLl4eFWff6a-AlA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83104997</pqid></control><display><type>article</type><title>Effect of Ethionine on the Transport of Cholesterol-4-C14 in Rat Lipoproteins</title><source>Wiley-Blackwell Journals (Backfile Content)</source><creator>Karvinen, Esko ; Miettinen, Matti</creator><creatorcontrib>Karvinen, Esko ; Miettinen, Matti</creatorcontrib><description>Ethionine administration to female rats resulted in a significant increase in the radioactivity of the chylomicron fraction after ingestion of cholesterol‐4‐C14. On the other hand, ethionine administration resulted in a marked decrease in the incorporation of radioactivity into the α1, lipoprotein fraction after ingestion of cholesterol‐4‐C14. In the normal rat 70 % of the radioactivity contained in the serum was found in the lipid of α1, lipoprotein whereas in the ethionine rats a trace of radioactivity only was found in the α2, fraction. There were no significant differences in the activities of the α2 and β lipoprotein fractions between the ethionine and control rats. It is concluded that liver damage by ethionine resulted in a specific inhibition of the formation of α1 lipoprotein.</description><identifier>ISSN: 0001-6772</identifier><identifier>EISSN: 1365-201X</identifier><identifier>DOI: 10.1111/j.1748-1716.1962.tb02493.x</identifier><identifier>PMID: 13962623</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological Transport ; Cholesterol - blood ; Chylomicrons ; Ethionine ; Lipoproteins ; Liver Diseases ; Old Medline ; Rats</subject><ispartof>Acta physiologica Scandinavica, 1962-10, Vol.56 (2), p.157-161</ispartof><rights>1962 Scandinavian Physiological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1748-1716.1962.tb02493.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1748-1716.1962.tb02493.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27924,27925,46049,46473</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13962623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karvinen, Esko</creatorcontrib><creatorcontrib>Miettinen, Matti</creatorcontrib><title>Effect of Ethionine on the Transport of Cholesterol-4-C14 in Rat Lipoproteins</title><title>Acta physiologica Scandinavica</title><addtitle>Acta Physiol Scand</addtitle><description>Ethionine administration to female rats resulted in a significant increase in the radioactivity of the chylomicron fraction after ingestion of cholesterol‐4‐C14. On the other hand, ethionine administration resulted in a marked decrease in the incorporation of radioactivity into the α1, lipoprotein fraction after ingestion of cholesterol‐4‐C14. In the normal rat 70 % of the radioactivity contained in the serum was found in the lipid of α1, lipoprotein whereas in the ethionine rats a trace of radioactivity only was found in the α2, fraction. There were no significant differences in the activities of the α2 and β lipoprotein fractions between the ethionine and control rats. It is concluded that liver damage by ethionine resulted in a specific inhibition of the formation of α1 lipoprotein.</description><subject>Animals</subject><subject>Biological Transport</subject><subject>Cholesterol - blood</subject><subject>Chylomicrons</subject><subject>Ethionine</subject><subject>Lipoproteins</subject><subject>Liver Diseases</subject><subject>Old Medline</subject><subject>Rats</subject><issn>0001-6772</issn><issn>1365-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><recordid>eNpFkMtOwzAQRS0EgvL4BRSxYOfgsR07WaGqlIIoD0F57CzHcVSXNC5JKsrfk9ACsxmN5s69o4PQCZAQ2jqbhSB5jEGCCCERNGxSQnnCwtUW6gETEaYE3rZRjxACWEhJ99B-Xc_akcWU7qI9YO2ZoKyHbod5bk0T-DwYNlPnS1fawJdBM7XBpNJlvfDVz3Yw9YWtG1v5AnM8AB64MnjUTTB2C7-ofGNdWR-inVwXtT3a9AP0fDmcDK7w-H50PeiPsaOMSWyAA9VZJiMZpdqkmYlNJLhhwLkkQgMzQqYSchbRNE4JiWksoyyFxORZnAl2gE7Xvm3wx7J9S81dbWxR6NL6Za1iBoQniWyFxxvhMp3bTC0qN9fVl_oF0ArO14JPV9iv_z1RHWo1Ux1q1aFWHWq1Qa1Wqv9w1Yeoi8BrB9fSWf056OpdCclkpF7vRuqJTe5uLl4eFWff6a-AlA</recordid><startdate>196210</startdate><enddate>196210</enddate><creator>Karvinen, Esko</creator><creator>Miettinen, Matti</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>196210</creationdate><title>Effect of Ethionine on the Transport of Cholesterol-4-C14 in Rat Lipoproteins</title><author>Karvinen, Esko ; Miettinen, Matti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2337-c1412add7575bacbdc8c564c3144706a13c67b71f352b8b0082875db19cfd8d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Animals</topic><topic>Biological Transport</topic><topic>Cholesterol - blood</topic><topic>Chylomicrons</topic><topic>Ethionine</topic><topic>Lipoproteins</topic><topic>Liver Diseases</topic><topic>Old Medline</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karvinen, Esko</creatorcontrib><creatorcontrib>Miettinen, Matti</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta physiologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karvinen, Esko</au><au>Miettinen, Matti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Ethionine on the Transport of Cholesterol-4-C14 in Rat Lipoproteins</atitle><jtitle>Acta physiologica Scandinavica</jtitle><addtitle>Acta Physiol Scand</addtitle><date>1962-10</date><risdate>1962</risdate><volume>56</volume><issue>2</issue><spage>157</spage><epage>161</epage><pages>157-161</pages><issn>0001-6772</issn><eissn>1365-201X</eissn><abstract>Ethionine administration to female rats resulted in a significant increase in the radioactivity of the chylomicron fraction after ingestion of cholesterol‐4‐C14. On the other hand, ethionine administration resulted in a marked decrease in the incorporation of radioactivity into the α1, lipoprotein fraction after ingestion of cholesterol‐4‐C14. In the normal rat 70 % of the radioactivity contained in the serum was found in the lipid of α1, lipoprotein whereas in the ethionine rats a trace of radioactivity only was found in the α2, fraction. There were no significant differences in the activities of the α2 and β lipoprotein fractions between the ethionine and control rats. It is concluded that liver damage by ethionine resulted in a specific inhibition of the formation of α1 lipoprotein.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>13962623</pmid><doi>10.1111/j.1748-1716.1962.tb02493.x</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0001-6772
ispartof Acta physiologica Scandinavica, 1962-10, Vol.56 (2), p.157-161
issn 0001-6772
1365-201X
language eng
recordid cdi_proquest_miscellaneous_83104997
source Wiley-Blackwell Journals (Backfile Content)
subjects Animals
Biological Transport
Cholesterol - blood
Chylomicrons
Ethionine
Lipoproteins
Liver Diseases
Old Medline
Rats
title Effect of Ethionine on the Transport of Cholesterol-4-C14 in Rat Lipoproteins
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T17%3A53%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Ethionine%20on%20the%20Transport%20of%20Cholesterol-4-C14%20in%20Rat%20Lipoproteins&rft.jtitle=Acta%20physiologica%20Scandinavica&rft.au=Karvinen,%20Esko&rft.date=1962-10&rft.volume=56&rft.issue=2&rft.spage=157&rft.epage=161&rft.pages=157-161&rft.issn=0001-6772&rft.eissn=1365-201X&rft_id=info:doi/10.1111/j.1748-1716.1962.tb02493.x&rft_dat=%3Cproquest_pubme%3E83104997%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-i2337-c1412add7575bacbdc8c564c3144706a13c67b71f352b8b0082875db19cfd8d63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=83104997&rft_id=info:pmid/13962623&rfr_iscdi=true