Interrelationship between oxygen-related variables in patients with acute myocardial infarction: an interpretative review

Summary The high mortality rate of cardiogenic shock in acute myocardial infarction (AMI) implies that debate over the correct haemodynamic management is still unresolved. The purpose of this review is to re‐evaluate the reciprocal relationships between oxygen‐related variables and response to treat...

Full description

Saved in:
Bibliographic Details
Published in:Clinical physiology and functional imaging 2010-11, Vol.30 (6), p.381-388
Main Authors: Jorge, Miguel A., Tavella, Margarita, Irrazábal, Célica L., Peralta, Jorge G., Capdevila, Abelardo A.
Format: Article
Language:English
Subjects:
Acidosis
Adaptation, Physiological
Aged
Aged, 80 and over
Biological and medical sciences
cardiogenic shock
Cardiology. Vascular system
cellular oxygen sensing
Coronary heart disease
Extraction
Heart
Hemodynamics
Humans
Management
Medical sciences
Middle Aged
Mortality
Myocardial infarction
Myocardial Infarction - complications
Myocardial Infarction - metabolism
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Myocardium - metabolism
Oxygen - metabolism
Oxygen Consumption
oxygen delivery
Oxygen demand
oxygen down-regulation
oxygen extraction ratio
Oxygen Inhalation Therapy
Patients
Shock, Cardiogenic - etiology
Shock, Cardiogenic - metabolism
Shock, Cardiogenic - physiopathology
Shock, Cardiogenic - therapy
Uptakes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The high mortality rate of cardiogenic shock in acute myocardial infarction (AMI) implies that debate over the correct haemodynamic management is still unresolved. The purpose of this review is to re‐evaluate the reciprocal relationships between oxygen‐related variables and response to treatment in a large number of patients with AMI. A MEDLINE search of reports published between 1970 and 2008 was performed. Twelve clinical reports including 453 patients with AMI and 989 sets of oxygen delivery and oxygen consumption expressed in ml min−1 m−2 and oxygen extraction ratio were selected. While processing this data, we found an early down‐regulation in oxygen demand linked to a decrease in oxygen supply. This mechanism is also supported in some studies by a critically low oxygen uptake that was not associated with lactic acidosis.
ISSN:1475-0961
1475-097X
DOI:10.1111/j.1475-097X.2010.00961.x