Update on the role of ovarian corticotropin-releasing hormone

Corticotropin‐releasing hormone (CRH) is a 41‐amino acid peptide synthesized by neurons of the parvocellular and paraventricular hypothalamic nuclei. Central CRH is the principal regulator of the stress system influencing several systems in the brain and influenced by them. It activates the secretio...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2010-09, Vol.1205 (1), p.225-229
Main Authors: Kiapekou, Erasmia, Zapanti, Evangelia, Mastorakos, George, Loutradis, Dimitris
Format: Article
Language:English
Subjects:
Corticotropin-Releasing Hormone - metabolism
Corticotropin-Releasing Hormone - physiology
CRH
CRH-R1
Endocrinology - trends
Female
Fluid dynamics
Hormones
Humans
Maturation
Neurons
oocyte maturation
Oogenesis - physiology
ovarian CRH
Ovaries
Ovary - metabolism
Peptides
Receptors, Corticotropin-Releasing Hormone - metabolism
Receptors, Corticotropin-Releasing Hormone - physiology
Reproduction
Reproductive system
Reproductive systems
Secretions
Steroids - biosynthesis
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Summary:Corticotropin‐releasing hormone (CRH) is a 41‐amino acid peptide synthesized by neurons of the parvocellular and paraventricular hypothalamic nuclei. Central CRH is the principal regulator of the stress system influencing several systems in the brain and influenced by them. It activates the secretion of glucocorticoids and indirectly regulates the immune system and the immune response. Peripheral CRH is secreted by postganglionic sympathetic and unmyelinated sensory afferent neurons and has been identified in several peripheral tissues and organs, including those of the reproductive system (ovary, endometrium, placenta, and testis). In the human ovary, receptors are detected in thecal and stromal cells and in follicular fluid. Ovarian CRH regulates ovarian steroidogenesis and is involved in follicular maturation, ovulation, and luteolysis. In this concise review we briefly discuss the role of ovarian CRH in reproduction, emphasizing its role in oocyte maturation.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2010.05685.x