Time-frequency coherence analysis of atrial fibrillation termination during procainamide administration

A time-frequency coherence estimator is developed and applied to study changes in signal characteristics as atrial fibrillation converts to sinus rhythm during administration of procainamide. A coherence spectrogram (CS) using multiple sinusoidal tapers is used in this study to assess phase relation...

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Bibliographic Details
Published in:Annals of biomedical engineering 1997-11, Vol.25 (6), p.975-984
Main Authors: LOVETT, E. G, ROPELLA, K. M
Format: Article
Language:English
Subjects:
Adult
Aged
Algorithms
Anti-Arrhythmia Agents - administration & dosage
Atrial Fibrillation - drug therapy
Biological and medical sciences
Cardiac arrhythmia
Computational methods
Diseases of the cardiovascular system
Drug products
Electrocardiography - drug effects
Fourier Analysis
Frequency domain analysis
Humans
Infusions, Intravenous
Medical sciences
Middle Aged
Procainamide - administration & dosage
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Signal processing
Signal Processing, Computer-Assisted
Sinuses
Spectrum analysis
Time domain analysis
Time Factors
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Summary:A time-frequency coherence estimator is developed and applied to study changes in signal characteristics as atrial fibrillation converts to sinus rhythm during administration of procainamide. A coherence spectrogram (CS) using multiple sinusoidal tapers is used in this study to assess phase relations between electrogram recordings at multiple atrial sites of seven patients who received procainamide to terminate atrial fibrillation. CSs are calculated (0 to 60 Hz) with 1 sec time resolution and 6.2 Hz frequency resolution. In agreement with previous studies, CSs generally exhibit low coherence during atrial fibrillation. Conversion to sinus rhythm is concomitant with an increase in coherence and emergence of structured time-frequency topography. Transition from atrial fibrillation to sinus rhythm is associated with a variety of time-frequency dynamics. Both gradual and abrupt increases in coherence coincide with conversion. Results suggest transient electrical organization in the atria during atrial fibrillation not seen in previous low-resolution coherence studies. CSs permit investigation of rhythm organization with unparalleled time and frequency resolution and thus are useful for studying transient changes in cardiac rhythms that may reflect underlying mechanisms.
ISSN:0090-6964
1573-9686
DOI:10.1007/BF02684133