Effects of nucleus on leukocyte recovery

The rheological properties of a leukocyte significantly affect its biological and mechanical characteristics. To date, existing physical models of leukocyte are not capable of quantitatively explaining the wide range of deformation and recovery behaviors observed in experiment. However, a compound d...

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Bibliographic Details
Published in:Annals of biomedical engineering 1999-09, Vol.27 (5), p.648-655
Main Authors: KAN, H.-C, SHYY, W, UDAYKUMAR, H. S, VIGNERON, P, TRAN-SON-TAY, R
Format: Article
Language:English
Subjects:
Behavior
Biological and medical sciences
Biomedical engineering
Cell Nucleus - metabolism
Computerized, statistical medical data processing and models in biomedicine
Cytoplasm
Eccentricity
Elasticity
Food science
Fundamental and applied biological sciences. Psychology
Hemodynamics. Rheology
Humans
In Vitro Techniques
Leukocytes
Leukocytes - cytology
Leukocytes - metabolism
Lymphocytes
Mathematical models
Medical sciences
Microscopy, Video
Models and simulation
Models, Cardiovascular
Nuclei
Recovery
Rheological properties
Rheology
Surface Properties
Vertebrates: cardiovascular system
Viscosity
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Summary:The rheological properties of a leukocyte significantly affect its biological and mechanical characteristics. To date, existing physical models of leukocyte are not capable of quantitatively explaining the wide range of deformation and recovery behaviors observed in experiment. However, a compound drop model has gained some success. In the present work, we investigate the effect of nucleus size and position, and the relative rheological properties of cytoplasm and nucleus, on cell recovery dynamics. Two nucleus sizes corresponding to that of neutrophil and lymphocyte are considered. Direct comparison between numerical simulations and experimental observation is made. Results indicate that the time scale ratio between the nucleus and cytoplasm plays an important role in cell recovery characteristics. Comparable time scales between the two cell components yield favorable agreement in recovery rates between numerical and experimental observations; disparate time scales, on the other hand, result in recovery behavior and cell shapes inconsistent with experiments. Furthermore, it is found that the nucleus eccentricity exhibits minimum influence on all major aspects of the cell recovery characteristics. The present work offers additional evidence in support of the compound cell model for predicting the rheological behavior of leukocytes.
ISSN:0090-6964
1573-9686
DOI:10.1114/1.214