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Susceptibility of Proteus mirabilis and its Stable L -Forms to Erythromycin and Other Macrolides
Proteus spp. and, other Gram-negative rods have been reported to be highly resistant to macrolides 1 , but nothing is known about the mechanism of this natural resistance. Using Proteus mirabilis I have compared the susceptibilities of the normal bacillary forms and the so-called stable L -forms. Th...
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| Published in: | Nature (London) 1962-10, Vol.196 (4850), p.195-196 |
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| Format: | Article |
| Language: | English |
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| container_end_page | 196 |
| container_issue | 4850 |
| container_start_page | 195 |
| container_title | Nature (London) |
| container_volume | 196 |
| creator | TAUBENECK, UDO |
| description | Proteus
spp. and, other Gram-negative rods have been reported to be highly resistant to macrolides
1
, but nothing is known about the mechanism of this natural resistance. Using
Proteus mirabilis
I have compared the susceptibilities of the normal bacillary forms and the so-called stable
L
-forms. The latter are distinguished by the absence of the cell walls of the parent strain. The absence has been demonstrated by the lack of phage receptors
2,3
and by chemical analysis
4
. In this respect they are similar to the protoplasts of Gram-positive bacteria produced by the action of lysozyme
5
; but, unlike these, they are able to grow well on solid media and may also be adapted to cultivation in broth. Like protoplasts, however, they do not revert to the normal rod forms, but grow indefinitely as
L
-forms even in the absence of penicillin, which was used for their induction in the first place. |
| doi_str_mv | 10.1038/196195b0 |
| format | article |
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spp. and, other Gram-negative rods have been reported to be highly resistant to macrolides
1
, but nothing is known about the mechanism of this natural resistance. Using
Proteus mirabilis
I have compared the susceptibilities of the normal bacillary forms and the so-called stable
L
-forms. The latter are distinguished by the absence of the cell walls of the parent strain. The absence has been demonstrated by the lack of phage receptors
2,3
and by chemical analysis
4
. In this respect they are similar to the protoplasts of Gram-positive bacteria produced by the action of lysozyme
5
; but, unlike these, they are able to grow well on solid media and may also be adapted to cultivation in broth. Like protoplasts, however, they do not revert to the normal rod forms, but grow indefinitely as
L
-forms even in the absence of penicillin, which was used for their induction in the first place.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/196195b0</identifier><identifier>PMID: 13993473</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Anti-Bacterial Agents ; Antibiotics, Antitubercular ; Erythromycin ; Humanities and Social Sciences ; letter ; Leucomycins ; Macrolides ; multidisciplinary ; Old Medline ; Oleandomycin ; Protein Synthesis Inhibitors ; Proteus ; Proteus mirabilis ; Science ; Science (multidisciplinary) ; Spiramycin</subject><ispartof>Nature (London), 1962-10, Vol.196 (4850), p.195-196</ispartof><rights>Springer Nature Limited 1962</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-3c1bf97603c243f0587181c7c7edfaa6a0ddb6aa0ee217b70a681cacc4fad8373</citedby><cites>FETCH-LOGICAL-c336t-3c1bf97603c243f0587181c7c7edfaa6a0ddb6aa0ee217b70a681cacc4fad8373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13993473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAUBENECK, UDO</creatorcontrib><title>Susceptibility of Proteus mirabilis and its Stable L -Forms to Erythromycin and Other Macrolides</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Proteus
spp. and, other Gram-negative rods have been reported to be highly resistant to macrolides
1
, but nothing is known about the mechanism of this natural resistance. Using
Proteus mirabilis
I have compared the susceptibilities of the normal bacillary forms and the so-called stable
L
-forms. The latter are distinguished by the absence of the cell walls of the parent strain. The absence has been demonstrated by the lack of phage receptors
2,3
and by chemical analysis
4
. In this respect they are similar to the protoplasts of Gram-positive bacteria produced by the action of lysozyme
5
; but, unlike these, they are able to grow well on solid media and may also be adapted to cultivation in broth. Like protoplasts, however, they do not revert to the normal rod forms, but grow indefinitely as
L
-forms even in the absence of penicillin, which was used for their induction in the first place.</description><subject>Anti-Bacterial Agents</subject><subject>Antibiotics, Antitubercular</subject><subject>Erythromycin</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Leucomycins</subject><subject>Macrolides</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Oleandomycin</subject><subject>Protein Synthesis Inhibitors</subject><subject>Proteus</subject><subject>Proteus mirabilis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Spiramycin</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLwzAUx4Mobk7BTyA5iR6qSdMl6VHGpsJkwvRcX9PUZbTNTNJDv72d29jN04P3__HjvT9C15Q8UMLkI005Tcc5OUFDmggeJVyKUzQkJJYRkYwP0IX3a0LImIrkHA0oS1OWCDZEX8vWK70JJjeVCR22JX53NujW49o42G49hqbAJni8DJBXGs9xNLOu9jhYPHVdWDlbd8o0f9wirLTDb6CcrUyh_SU6K6Hy-mo_R-hzNv2YvETzxfPr5GkeKcZ4iJiieZkKTpiKE1aSsRRUUiWU0EUJwIEURc4BiNYxFbkgwPsYlEpKKCQTbIRud96Nsz-t9iGrTf9ZVUGjbeszySiVPOY9eLcD-wu9d7rMNs7U4LqMkmzbZnZos0dv9s42r3VxBPf19cD9DvB91Hxrl61t65r-z39kDYTW6aPsAPwCbIOHiA</recordid><startdate>19621013</startdate><enddate>19621013</enddate><creator>TAUBENECK, UDO</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19621013</creationdate><title>Susceptibility of Proteus mirabilis and its Stable L -Forms to Erythromycin and Other Macrolides</title><author>TAUBENECK, UDO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-3c1bf97603c243f0587181c7c7edfaa6a0ddb6aa0ee217b70a681cacc4fad8373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Anti-Bacterial Agents</topic><topic>Antibiotics, Antitubercular</topic><topic>Erythromycin</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Leucomycins</topic><topic>Macrolides</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Oleandomycin</topic><topic>Protein Synthesis Inhibitors</topic><topic>Proteus</topic><topic>Proteus mirabilis</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Spiramycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAUBENECK, UDO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAUBENECK, UDO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibility of Proteus mirabilis and its Stable L -Forms to Erythromycin and Other Macrolides</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1962-10-13</date><risdate>1962</risdate><volume>196</volume><issue>4850</issue><spage>195</spage><epage>196</epage><pages>195-196</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Proteus
spp. and, other Gram-negative rods have been reported to be highly resistant to macrolides
1
, but nothing is known about the mechanism of this natural resistance. Using
Proteus mirabilis
I have compared the susceptibilities of the normal bacillary forms and the so-called stable
L
-forms. The latter are distinguished by the absence of the cell walls of the parent strain. The absence has been demonstrated by the lack of phage receptors
2,3
and by chemical analysis
4
. In this respect they are similar to the protoplasts of Gram-positive bacteria produced by the action of lysozyme
5
; but, unlike these, they are able to grow well on solid media and may also be adapted to cultivation in broth. Like protoplasts, however, they do not revert to the normal rod forms, but grow indefinitely as
L
-forms even in the absence of penicillin, which was used for their induction in the first place.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>13993473</pmid><doi>10.1038/196195b0</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1962-10, Vol.196 (4850), p.195-196 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | Springer Nature - Connect here FIRST to enable access |
| subjects | Anti-Bacterial Agents Antibiotics, Antitubercular Erythromycin Humanities and Social Sciences letter Leucomycins Macrolides multidisciplinary Old Medline Oleandomycin Protein Synthesis Inhibitors Proteus Proteus mirabilis Science Science (multidisciplinary) Spiramycin |
| title | Susceptibility of Proteus mirabilis and its Stable L -Forms to Erythromycin and Other Macrolides |
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