Tumors Induced in Primates by Chicken Sarcoma Virus

A suspension of a variant of Rous sarcoma was injected into four adult and eight newborn rhesus monkeys. Seven newborns developed tumors, three of which were diagnosed as fibrosarcomas, in 2 to 6 weeks; none of the adults have tumors after 11 weeks. Virus was demonstrated in two of the tumors by inj...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1963-06, Vol.140 (3574), p.1415-1416
Main Authors: Munroe, J. Spencer, Windle, William F.
Format: Article
Language:English
Subjects:
Animals
Avian Sarcoma Viruses
Cancer
Chickens
Fibrosarcoma
Histology
Meat
Neoplasms
Newborns
Old Medline
Physiology
Primates
Rous sarcoma virus
Sarcoma
Sarcoma, Avian
Sarcoma, Experimental
Tumors
Viruses
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Summary:A suspension of a variant of Rous sarcoma was injected into four adult and eight newborn rhesus monkeys. Seven newborns developed tumors, three of which were diagnosed as fibrosarcomas, in 2 to 6 weeks; none of the adults have tumors after 11 weeks. Virus was demonstrated in two of the tumors by injecting a tumor-suspension preparation into the chick wing-web where tumors subsequently appeared. To the best of our knowledge this is the first time that sarcomas have developed in primates after a virus has been injected.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.140.3574.1415