Passive Cutaneous Anaphylaxis with Antibody Fragments

Pepsin-digested rabbit antibody (5S) provoked reverse passive cutaneous anaphylaxis in the guinea pig, but was somewhat less effective, mole for mole, than the native antibody. Fixation of guinea pig complement by the pepsindigested antibody could not be demonstrated either in vitro or in vivo. Spli...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1963-04, Vol.140 (3563), p.193-195
Main Authors: Ovary, Zoltan, Taranta, Angelo
Format: Article
Language:English
Subjects:
Anaphylaxis
Animals
Antibodies
Antigen-Antibody Reactions
Antigens
Circles
Complement System Proteins
Diluents
Guinea Pigs
Immediate hypersensitivity
Immunoglobulin Fragments
Old Medline
Ovaries
Passive Cutaneous Anaphylaxis
Rabbits
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Summary:Pepsin-digested rabbit antibody (5S) provoked reverse passive cutaneous anaphylaxis in the guinea pig, but was somewhat less effective, mole for mole, than the native antibody. Fixation of guinea pig complement by the pepsindigested antibody could not be demonstrated either in vitro or in vivo. Splitting of the 5S fragment into two monovalent fragments (3.5S) markedly reduced the capacity to provoke reverse passive cutaneous anaphylaxis.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.140.3563.193