Vascular and neuroglial changes in experimental herpes simplex encephalitis: ultrastructural study

Generalized vascular changes and diffused proliferation of reactive microglia were observed in an experimental model of HSV encephalitis of mice. The wide spread of these changes contrasted with the localized character of virus replication and the confined areas of damaged nervous tissue. The vascul...

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Bibliographic Details
Published in:Acta neuropathologica 1975-12, Vol.33 (3), p.245-256
Main Authors: Arsénio-Nunes, M L, Cerutti, I, Farkas-Bargeton, E
Format: Article
Language:English
Subjects:
Animals
Basement Membrane - ultrastructure
Capillaries - ultrastructure
Central Nervous System - pathology
Cerebral Cortex - ultrastructure
Cytopathogenic Effect, Viral
Disease Models, Animal
Encephalitis - pathology
Endothelium - ultrastructure
Herpes Simplex - pathology
Hippocampus - ultrastructure
Mice
Mice, Inbred BALB C
Microcirculation - ultrastructure
Neuroglia - ultrastructure
Simplexvirus - pathogenicity
Simplexvirus - radiation effects
Ultraviolet Rays
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Summary:Generalized vascular changes and diffused proliferation of reactive microglia were observed in an experimental model of HSV encephalitis of mice. The wide spread of these changes contrasted with the localized character of virus replication and the confined areas of damaged nervous tissue. The vascular and microglial changes were precocious in animals inoculated with concentrated virus suspension (10(5.5)LD50) while they appeared late in mice inoculated with diluted virus suspension (100 LD50). After inoculation with U.V. inactivated virus no changes were seen. The results obtained in this study suggest that the vascular and microglial modifications are not related to a direct cytopathic effect of the virus but dependent on the amount of virus present in the central nervous system and linked to the virus DNA.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00688397