Antihistaminic Action of Lysozyme

IT was previously shown that heparin and mucin bind histamine 1,2 . For this reason we worked with an enzyme acting on mucopolysaccharides, and looked for some modifications of histamine action. Lysozyme inhibits the action of histamine on the isolated guinea pig's ileum. The threshold is about...

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Bibliographic Details
Published in:Nature (London) 1963-02, Vol.197 (4866), p.496-496
Main Authors: PARROT, JEAN-LOUIS, NICOT, GEORGES
Format: Article
Language:English
Subjects:
Antiviral Agents
Dermatologic Agents
Histamine H1 Antagonists
Humanities and Social Sciences
letter
multidisciplinary
Muramidase
Old Medline
Science
Science (multidisciplinary)
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Summary:IT was previously shown that heparin and mucin bind histamine 1,2 . For this reason we worked with an enzyme acting on mucopolysaccharides, and looked for some modifications of histamine action. Lysozyme inhibits the action of histamine on the isolated guinea pig's ileum. The threshold is about 10 −9 (w/v). No inhibitor action was observed towards acetylcholine, serotonin and barium.
ISSN:0028-0836
1476-4687
DOI:10.1038/197496a0