Pulmonary Arterial Tree following Prolonged Experimental Reduction of Pulmonary Blood Flow

A Blalock anastomosis between the left subclavian artery and the left pulmonary artery was performed on six dogs soon after birth. As an unexpected complication of surgery, blood flow through the left lungs of two of the dogs was greatly reduced. Over a period of 22 months, widespread arterial throm...

Full description

Saved in:
Bibliographic Details
Published in:Circulation research 1963-01, Vol.12 (1), p.101-106
Main Authors: Naeye, Richard L, Kusserow, Bert K, Jacobson, Julius H
Format: Article
Language:English
Subjects:
Cardiovascular System
Lung
Old Medline
Pulmonary Artery
Pulmonary Circulation
Pulmonary Valve Stenosis
Subclavian Artery
Thrombosis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4155-7a1517ed9cd2004f0a1cdcc445a3be7eb738382bf12f30423d8d5e2210a80c9b3
cites
container_end_page 106
container_issue 1
container_start_page 101
container_title Circulation research
container_volume 12
creator Naeye, Richard L
Kusserow, Bert K
Jacobson, Julius H
description A Blalock anastomosis between the left subclavian artery and the left pulmonary artery was performed on six dogs soon after birth. As an unexpected complication of surgery, blood flow through the left lungs of two of the dogs was greatly reduced. Over a period of 22 months, widespread arterial thromboses developed in these two lungs. The thrombotic lesions were comparable to those which develop in human beings with severe pulmonic valvular stenosis or atresia. Hypoxemia and polycythemia have often been implicated in the development of these lesions. Our study demonstrates that such lesions can be induced in the dog by reduction in pulmonary blood flow alone since hypoxemia and polycythemia were absent in our experimental animals.
doi_str_mv 10.1161/01.RES.12.1.101
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_83201229</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83201229</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4155-7a1517ed9cd2004f0a1cdcc445a3be7eb738382bf12f30423d8d5e2210a80c9b3</originalsourceid><addsrcrecordid>eNpFkE1LxDAQhoMoun6cvUlP3lpnktS2R5VdFQTFj4uXkCZTXc02a9Ky-u-N7IKHMGR45k3mYewYoUA8xzPA4nH6VCAvsEDALTbBkstclhVuswkANHklBOyx_Rg_AFAK3uyyPRSNqKDCCXt9GN3C9zr8ZBdhoDDXLnsORFnnnfOref-WPQTvfP9GNpt-LxOxoH5I1CPZ0Qxz32e-y_5TLp33Npul2UO202kX6WhTD9jLbPp8dZPf3V_fXl3c5UZiWeaVxhIrso2xHEB2oNFYY6QstWiporYStah52yHvBEgubG1L4hxB12CaVhyw03XuMvivkeKgFvNoyDndkx-jqgUH5LxJ4NkaNMHHGKhTy7RN-rRCUH86FaBKOhVyhamHaeJkEz22C7L__MZfAuQaWHmX7MVPN64oqHfSbnhXyT-I9HaOzXmq6Zang6X4BV0ZgGM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83201229</pqid></control><display><type>article</type><title>Pulmonary Arterial Tree following Prolonged Experimental Reduction of Pulmonary Blood Flow</title><source>Freely Accessible Journals</source><creator>Naeye, Richard L ; Kusserow, Bert K ; Jacobson, Julius H</creator><creatorcontrib>Naeye, Richard L ; Kusserow, Bert K ; Jacobson, Julius H</creatorcontrib><description>A Blalock anastomosis between the left subclavian artery and the left pulmonary artery was performed on six dogs soon after birth. As an unexpected complication of surgery, blood flow through the left lungs of two of the dogs was greatly reduced. Over a period of 22 months, widespread arterial thromboses developed in these two lungs. The thrombotic lesions were comparable to those which develop in human beings with severe pulmonic valvular stenosis or atresia. Hypoxemia and polycythemia have often been implicated in the development of these lesions. Our study demonstrates that such lesions can be induced in the dog by reduction in pulmonary blood flow alone since hypoxemia and polycythemia were absent in our experimental animals.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.12.1.101</identifier><identifier>PMID: 13937071</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Cardiovascular System ; Lung ; Old Medline ; Pulmonary Artery ; Pulmonary Circulation ; Pulmonary Valve Stenosis ; Subclavian Artery ; Thrombosis</subject><ispartof>Circulation research, 1963-01, Vol.12 (1), p.101-106</ispartof><rights>1963 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4155-7a1517ed9cd2004f0a1cdcc445a3be7eb738382bf12f30423d8d5e2210a80c9b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13937071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naeye, Richard L</creatorcontrib><creatorcontrib>Kusserow, Bert K</creatorcontrib><creatorcontrib>Jacobson, Julius H</creatorcontrib><title>Pulmonary Arterial Tree following Prolonged Experimental Reduction of Pulmonary Blood Flow</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>A Blalock anastomosis between the left subclavian artery and the left pulmonary artery was performed on six dogs soon after birth. As an unexpected complication of surgery, blood flow through the left lungs of two of the dogs was greatly reduced. Over a period of 22 months, widespread arterial thromboses developed in these two lungs. The thrombotic lesions were comparable to those which develop in human beings with severe pulmonic valvular stenosis or atresia. Hypoxemia and polycythemia have often been implicated in the development of these lesions. Our study demonstrates that such lesions can be induced in the dog by reduction in pulmonary blood flow alone since hypoxemia and polycythemia were absent in our experimental animals.</description><subject>Cardiovascular System</subject><subject>Lung</subject><subject>Old Medline</subject><subject>Pulmonary Artery</subject><subject>Pulmonary Circulation</subject><subject>Pulmonary Valve Stenosis</subject><subject>Subclavian Artery</subject><subject>Thrombosis</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LxDAQhoMoun6cvUlP3lpnktS2R5VdFQTFj4uXkCZTXc02a9Ky-u-N7IKHMGR45k3mYewYoUA8xzPA4nH6VCAvsEDALTbBkstclhVuswkANHklBOyx_Rg_AFAK3uyyPRSNqKDCCXt9GN3C9zr8ZBdhoDDXLnsORFnnnfOref-WPQTvfP9GNpt-LxOxoH5I1CPZ0Qxz32e-y_5TLp33Npul2UO202kX6WhTD9jLbPp8dZPf3V_fXl3c5UZiWeaVxhIrso2xHEB2oNFYY6QstWiporYStah52yHvBEgubG1L4hxB12CaVhyw03XuMvivkeKgFvNoyDndkx-jqgUH5LxJ4NkaNMHHGKhTy7RN-rRCUH86FaBKOhVyhamHaeJkEz22C7L__MZfAuQaWHmX7MVPN64oqHfSbnhXyT-I9HaOzXmq6Zang6X4BV0ZgGM</recordid><startdate>196301</startdate><enddate>196301</enddate><creator>Naeye, Richard L</creator><creator>Kusserow, Bert K</creator><creator>Jacobson, Julius H</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196301</creationdate><title>Pulmonary Arterial Tree following Prolonged Experimental Reduction of Pulmonary Blood Flow</title><author>Naeye, Richard L ; Kusserow, Bert K ; Jacobson, Julius H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4155-7a1517ed9cd2004f0a1cdcc445a3be7eb738382bf12f30423d8d5e2210a80c9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Cardiovascular System</topic><topic>Lung</topic><topic>Old Medline</topic><topic>Pulmonary Artery</topic><topic>Pulmonary Circulation</topic><topic>Pulmonary Valve Stenosis</topic><topic>Subclavian Artery</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naeye, Richard L</creatorcontrib><creatorcontrib>Kusserow, Bert K</creatorcontrib><creatorcontrib>Jacobson, Julius H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naeye, Richard L</au><au>Kusserow, Bert K</au><au>Jacobson, Julius H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary Arterial Tree following Prolonged Experimental Reduction of Pulmonary Blood Flow</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1963-01</date><risdate>1963</risdate><volume>12</volume><issue>1</issue><spage>101</spage><epage>106</epage><pages>101-106</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>A Blalock anastomosis between the left subclavian artery and the left pulmonary artery was performed on six dogs soon after birth. As an unexpected complication of surgery, blood flow through the left lungs of two of the dogs was greatly reduced. Over a period of 22 months, widespread arterial thromboses developed in these two lungs. The thrombotic lesions were comparable to those which develop in human beings with severe pulmonic valvular stenosis or atresia. Hypoxemia and polycythemia have often been implicated in the development of these lesions. Our study demonstrates that such lesions can be induced in the dog by reduction in pulmonary blood flow alone since hypoxemia and polycythemia were absent in our experimental animals.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>13937071</pmid><doi>10.1161/01.RES.12.1.101</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0009-7330
ispartof Circulation research, 1963-01, Vol.12 (1), p.101-106
issn 0009-7330
1524-4571
language eng
recordid cdi_proquest_miscellaneous_83201229
source Freely Accessible Journals
subjects Cardiovascular System
Lung
Old Medline
Pulmonary Artery
Pulmonary Circulation
Pulmonary Valve Stenosis
Subclavian Artery
Thrombosis
title Pulmonary Arterial Tree following Prolonged Experimental Reduction of Pulmonary Blood Flow
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T11%3A54%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pulmonary%20Arterial%20Tree%20following%20Prolonged%20Experimental%20Reduction%20of%20Pulmonary%20Blood%20Flow&rft.jtitle=Circulation%20research&rft.au=Naeye,%20Richard%20L&rft.date=1963-01&rft.volume=12&rft.issue=1&rft.spage=101&rft.epage=106&rft.pages=101-106&rft.issn=0009-7330&rft.eissn=1524-4571&rft_id=info:doi/10.1161/01.RES.12.1.101&rft_dat=%3Cproquest_cross%3E83201229%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4155-7a1517ed9cd2004f0a1cdcc445a3be7eb738382bf12f30423d8d5e2210a80c9b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=83201229&rft_id=info:pmid/13937071&rfr_iscdi=true