Electrolyte Effect of Cardiac Glycosides on Dog's Heart-Lung Preparation

The electrolyte effect of the rapid acting heart glycoside convallatoxin was investigated on heart‐lung preparations of dog, labelled with 42K and 24Na. Total concentrations of plasma potassium and sodium were determined by flame photometry. The radioactivity of plasma, heart lymph and myocardial sa...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1962-06, Vol.55 (2-3), p.264-269
Main Author: Areskog, N.-H.
Format: Article
Language:English
Subjects:
Animals
Anions
Cardiac Glycosides
Convallaria - pharmacology
Dogs
Electrolytes
Humans
Ions
Old Medline
Potassium - metabolism
Sodium - metabolism
Sodium, Dietary
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Summary:The electrolyte effect of the rapid acting heart glycoside convallatoxin was investigated on heart‐lung preparations of dog, labelled with 42K and 24Na. Total concentrations of plasma potassium and sodium were determined by flame photometry. The radioactivity of plasma, heart lymph and myocardial samples was determined by gamma spectrometry. A net loss of potassium from the myocardium was induced by the glycoside but there was not a corresponding loss of 42K. This means that isotopic equilibrium was not attained in spite of an ‘equilibration’ time of 60—90 min and the conclusion is drawn that the glycoside mainly affected a part of the intracellular myocardial potassium which has a relatively slow exchange rate. The changes in heart lymph were principally the same as in plasma. No significant changes of the sodium balance due to the glycoside action was found.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1962.tb02439.x