Hyperphagia and Increased Growth in Rats After Intraventricular Injection of 5,7-Dihydroxytryptamine

Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats. Biochemical analyses of brain tissue obtained 50 to 140 da...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1976-04, Vol.192 (4237), p.385-387
Main Authors: Saller, Charles F., Stricker, Edward M.
Format: Article
Language:English
Subjects:
Animals
Behavioral neuroscience
Body weight
Body Weight - drug effects
Brain
Brain Chemistry - drug effects
Brain damage
Feeding Behavior - drug effects
Food intake
Hyperphagia
Intraventricular injections
Neurons
Norepinephrine
Norepinephrine - analysis
Rats
Satiation - drug effects
Serotonin - analysis
Tibia
Tibia - growth & development
Tryptamines - pharmacology
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Summary:Juvenile male rats given intracerebroventricular injections of 5,7-dihydroxytryptamine, following treatment with desmethylimipramine, maintained body weight gains of 5 to 6 grams per day into adulthood and grew much larger than control rats. Biochemical analyses of brain tissue obtained 50 to 140 days after the injections revealed 60 to 86 percent depletions of telencephalic 5-hydroxytryptamine, with catecholamine levels unchanged. Hyperphagia did not develop despite comparable losses of 5-hydroxytryptamine when the pretreatment was withheld, perhaps because substantial depletions of norepinephrine occurred as well.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1257774