Hexokinase Activity as a Function of Age of the Human Erythrocyte

THE human erythrocyte normally survives in the circulation approximately 120 days. The factors which limit the cell's survival are unknown. An important factor may be an age-related diminution in the activity of one or more enzymes vital to the cell 1 . A decrease in the activity of a key glyco...

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Bibliographic Details
Published in:Nature (London) 1963-08, Vol.199 (4894), p.704-705
Main Authors: BREWER, GEORGE J, POWELL, ROBIN D
Format: Article
Language:English
Subjects:
Aging
Carbohydrate Metabolism
Erythrocytes
Glucosephosphate Dehydrogenase
Hexokinase
Humanities and Social Sciences
Humans
letter
multidisciplinary
Old Medline
Oxidoreductases
Phosphorylation
Reticulocytes
Science
Science (multidisciplinary)
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Summary:THE human erythrocyte normally survives in the circulation approximately 120 days. The factors which limit the cell's survival are unknown. An important factor may be an age-related diminution in the activity of one or more enzymes vital to the cell 1 . A decrease in the activity of a key glycolytic enzyme, or enzymes, might be of particular importance because the mature human red cell derives virtually all its energy through glycolysis. Certain inherited enzymatic defects, both in the anaerobic glycolytic and in the pentose phosphate pathways of the human red cell, are associated with shortening of the lifespan of the cell 2–5 .
ISSN:0028-0836
1476-4687
DOI:10.1038/199704a0