G-Banding Analysis of Complex Aneuploidy in Multiple Myeloma Bone Marrow Cells

Chromosome studies with the banding technique have been performed in a considerable number of cases of myeloproliferative diseases, but technical difficulties have so far prevented detailed studies of chromosomal abnormalities in multiple myeloma. The karyotypes of bone marrow cells from two patient...

Full description

Saved in:
Bibliographic Details
Published in:Blood 1976-01, Vol.47 (1), p.69-77
Main Authors: Philip, Preben, Drivsholm, Aage
Format: Article
Language:English
Subjects:
Aged
Aneuploidy
Bone Marrow - ultrastructure
Bone Marrow Cells
Chromosome Aberrations
Chromosomes, Human, 1-3
Chromosomes, Human, 16-18
Humans
Karyotyping
Male
Middle Aged
Multiple Myeloma - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chromosome studies with the banding technique have been performed in a considerable number of cases of myeloproliferative diseases, but technical difficulties have so far prevented detailed studies of chromosomal abnormalities in multiple myeloma. The karyotypes of bone marrow cells from two patients with multiple myeloma have been analyzed by a trypsin-Giemsa banding technique. Evidence is given for clonal evolution which in one patient has probably occurred by cell fusion and subsequent chromosome loss. Eight different marker chromosomes are characterized. Nonrandom chromosomal participation in the translocations and the existence of specific vulnerable points on chromosomes 1, 3, and 16 are suggested.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V47.1.69.69