The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells

It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1976-01, Vol.191 (4223), p.191-192
Main Authors: Pictet, Raymond L., Rall, Leslie B., Phelps, Patricia, Rutter, William J.
Format: Article
Language:English
Subjects:
Amines - metabolism
Animals
APUD cells
B lymphocytes
Cell Differentiation
Cultured cells
Digestive System - embryology
Ectoderm - metabolism
Ectoderm - physiology
Embryos
Endocrine cells
Endocrine Glands - embryology
Gastrointestinal Hormones - biosynthesis
Insulin
Insulin - biosynthesis
Islet cells
Islets of Langerhans - embryology
Nervous System - embryology
Neural crest
Neurons
Pancreas
Rats
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Summary:It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for 11 days. In every case where a pancreas developed, insulin was detected or B cells were observed. Thus, a neural crest origin for these cells is eliminated.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1108195