Loading…

The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells

It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) 1976-01, Vol.191 (4223), p.191-192
Main Authors:	Pictet, Raymond L., Rall, Leslie B., Phelps, Patricia, Rutter, William J.
Format:	Article
Language:	English
Subjects:	Amines - metabolism Animals APUD cells B lymphocytes Cell Differentiation Cultured cells Digestive System - embryology Ectoderm - metabolism Ectoderm - physiology Embryos Endocrine cells Endocrine Glands - embryology Gastrointestinal Hormones - biosynthesis Insulin Insulin - biosynthesis Islet cells Islets of Langerhans - embryology Nervous System - embryology Neural crest Neurons Pancreas Rats
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c409t-1de07b55038494748eef1a7bb26a76ff37946fd49caacd6bec9b408861c441a23
cites	cdi_FETCH-LOGICAL-c409t-1de07b55038494748eef1a7bb26a76ff37946fd49caacd6bec9b408861c441a23
container_end_page	192
container_issue	4223
container_start_page	191
container_title	Science (American Association for the Advancement of Science)
container_volume	191
creator	Pictet, Raymond L. Rall, Leslie B. Phelps, Patricia Rutter, William J.
description	It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for 11 days. In every case where a pancreas developed, insulin was detected or B cells were observed. Thus, a neural crest origin for these cells is eliminated.
doi_str_mv	10.1126/science.1108195
format	article
fullrecord	<record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_83262040</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>1742032</jstor_id><sourcerecordid>1742032</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-1de07b55038494748eef1a7bb26a76ff37946fd49caacd6bec9b408861c441a23</originalsourceid><addsrcrecordid>eNpNkTFPwzAQhS0EKqUws4CUiS30HDtOPKIK2koVZShz5DhOcUnsYicD_x7TRpTpdPe-ezq9Q-gWwyPGCZt6qZWRKjSQY56eoTEGnsY8AXKOxgCExTlk6SW68n4HEDRORmg04GP0uflQ0avqnWiimVO-i4Spoi4M105vtYlsfeiWxveNNvGbs1UvtdkeuHWQXDQXvnNWmy6saxOMFta11qh_8Ew1jb9GF7VovLoZ6gS9vzxvZot4tZ4vZ0-rWFLgXYwrBVmZpkByymlGc6VqLLKyTJjIWF2TjFNWV5RLIWTFSiV5SSHPGZaUYpGQCXo4-u6d_erDUUWrvQwXCKNs74ucJCwBCgGcHkHprPdO1cXe6Va47wJD8RtvMcRbDHmFjfvBui9bVZ34P_3uqO98Z91Jzmh4SEJ-AMj0gZs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83262040</pqid></control><display><type>article</type><title>The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells</title><source>Science Magazine</source><source>JSTOR Archival Journals and Primary Sources Collection</source><creator>Pictet, Raymond L. ; Rall, Leslie B. ; Phelps, Patricia ; Rutter, William J.</creator><creatorcontrib>Pictet, Raymond L. ; Rall, Leslie B. ; Phelps, Patricia ; Rutter, William J.</creatorcontrib><description>It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for 11 days. In every case where a pancreas developed, insulin was detected or B cells were observed. Thus, a neural crest origin for these cells is eliminated.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1108195</identifier><identifier>PMID: 1108195</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Amines - metabolism ; Animals ; APUD cells ; B lymphocytes ; Cell Differentiation ; Cultured cells ; Digestive System - embryology ; Ectoderm - metabolism ; Ectoderm - physiology ; Embryos ; Endocrine cells ; Endocrine Glands - embryology ; Gastrointestinal Hormones - biosynthesis ; Insulin ; Insulin - biosynthesis ; Islet cells ; Islets of Langerhans - embryology ; Nervous System - embryology ; Neural crest ; Neurons ; Pancreas ; Rats</subject><ispartof>Science (American Association for the Advancement of Science), 1976-01, Vol.191 (4223), p.191-192</ispartof><rights>Copyright 1976 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-1de07b55038494748eef1a7bb26a76ff37946fd49caacd6bec9b408861c441a23</citedby><cites>FETCH-LOGICAL-c409t-1de07b55038494748eef1a7bb26a76ff37946fd49caacd6bec9b408861c441a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1742032$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1742032$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,2870,2871,27903,27904,58216,58449</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1108195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pictet, Raymond L.</creatorcontrib><creatorcontrib>Rall, Leslie B.</creatorcontrib><creatorcontrib>Phelps, Patricia</creatorcontrib><creatorcontrib>Rutter, William J.</creatorcontrib><title>The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for 11 days. In every case where a pancreas developed, insulin was detected or B cells were observed. Thus, a neural crest origin for these cells is eliminated.</description><subject>Amines - metabolism</subject><subject>Animals</subject><subject>APUD cells</subject><subject>B lymphocytes</subject><subject>Cell Differentiation</subject><subject>Cultured cells</subject><subject>Digestive System - embryology</subject><subject>Ectoderm - metabolism</subject><subject>Ectoderm - physiology</subject><subject>Embryos</subject><subject>Endocrine cells</subject><subject>Endocrine Glands - embryology</subject><subject>Gastrointestinal Hormones - biosynthesis</subject><subject>Insulin</subject><subject>Insulin - biosynthesis</subject><subject>Islet cells</subject><subject>Islets of Langerhans - embryology</subject><subject>Nervous System - embryology</subject><subject>Neural crest</subject><subject>Neurons</subject><subject>Pancreas</subject><subject>Rats</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><recordid>eNpNkTFPwzAQhS0EKqUws4CUiS30HDtOPKIK2koVZShz5DhOcUnsYicD_x7TRpTpdPe-ezq9Q-gWwyPGCZt6qZWRKjSQY56eoTEGnsY8AXKOxgCExTlk6SW68n4HEDRORmg04GP0uflQ0avqnWiimVO-i4Spoi4M105vtYlsfeiWxveNNvGbs1UvtdkeuHWQXDQXvnNWmy6saxOMFta11qh_8Ew1jb9GF7VovLoZ6gS9vzxvZot4tZ4vZ0-rWFLgXYwrBVmZpkByymlGc6VqLLKyTJjIWF2TjFNWV5RLIWTFSiV5SSHPGZaUYpGQCXo4-u6d_erDUUWrvQwXCKNs74ucJCwBCgGcHkHprPdO1cXe6Va47wJD8RtvMcRbDHmFjfvBui9bVZ34P_3uqO98Z91Jzmh4SEJ-AMj0gZs</recordid><startdate>19760116</startdate><enddate>19760116</enddate><creator>Pictet, Raymond L.</creator><creator>Rall, Leslie B.</creator><creator>Phelps, Patricia</creator><creator>Rutter, William J.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19760116</creationdate><title>The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells</title><author>Pictet, Raymond L. ; Rall, Leslie B. ; Phelps, Patricia ; Rutter, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-1de07b55038494748eef1a7bb26a76ff37946fd49caacd6bec9b408861c441a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Amines - metabolism</topic><topic>Animals</topic><topic>APUD cells</topic><topic>B lymphocytes</topic><topic>Cell Differentiation</topic><topic>Cultured cells</topic><topic>Digestive System - embryology</topic><topic>Ectoderm - metabolism</topic><topic>Ectoderm - physiology</topic><topic>Embryos</topic><topic>Endocrine cells</topic><topic>Endocrine Glands - embryology</topic><topic>Gastrointestinal Hormones - biosynthesis</topic><topic>Insulin</topic><topic>Insulin - biosynthesis</topic><topic>Islet cells</topic><topic>Islets of Langerhans - embryology</topic><topic>Nervous System - embryology</topic><topic>Neural crest</topic><topic>Neurons</topic><topic>Pancreas</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pictet, Raymond L.</creatorcontrib><creatorcontrib>Rall, Leslie B.</creatorcontrib><creatorcontrib>Phelps, Patricia</creatorcontrib><creatorcontrib>Rutter, William J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pictet, Raymond L.</au><au>Rall, Leslie B.</au><au>Phelps, Patricia</au><au>Rutter, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1976-01-16</date><risdate>1976</risdate><volume>191</volume><issue>4223</issue><spage>191</spage><epage>192</epage><pages>191-192</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>It has been proposed that the endocrine cells of the digestive tract derive from the neuroectoderm (neural crest). To test this hypothesis we removed the entire ectoderm, the precursor of the neural crest, of embryonic rats prior to the formation of the neural crest and cultured the mesoendoderm for 11 days. In every case where a pancreas developed, insulin was detected or B cells were observed. Thus, a neural crest origin for these cells is eliminated.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>1108195</pmid><doi>10.1126/science.1108195</doi><tpages>2</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0036-8075
ispartof	Science (American Association for the Advancement of Science), 1976-01, Vol.191 (4223), p.191-192
issn	0036-8075 1095-9203
language	eng
recordid	cdi_proquest_miscellaneous_83262040
source	Science Magazine; JSTOR Archival Journals and Primary Sources Collection
subjects	Amines - metabolism Animals APUD cells B lymphocytes Cell Differentiation Cultured cells Digestive System - embryology Ectoderm - metabolism Ectoderm - physiology Embryos Endocrine cells Endocrine Glands - embryology Gastrointestinal Hormones - biosynthesis Insulin Insulin - biosynthesis Islet cells Islets of Langerhans - embryology Nervous System - embryology Neural crest Neurons Pancreas Rats
title	The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T02%3A06%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Neural%20Crest%20and%20the%20Origin%20of%20the%20Insulin-Producing%20and%20Other%20Gastrointestinal%20Hormone-Producing%20Cells&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Pictet,%20Raymond%20L.&rft.date=1976-01-16&rft.volume=191&rft.issue=4223&rft.spage=191&rft.epage=192&rft.pages=191-192&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.1108195&rft_dat=%3Cjstor_proqu%3E1742032%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c409t-1de07b55038494748eef1a7bb26a76ff37946fd49caacd6bec9b408861c441a23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=83262040&rft_id=info:pmid/1108195&rft_jstor_id=1742032&rfr_iscdi=true