The effect of amiloride on the transepithelial potential difference of the distal tubule of the rat kidney

Microelectrodes with relatively large tips (3-5 mu O.D.) were used to measure the transepithelial potential difference (PD) of the distal tubule of the rat kidney in the control state and following i.v. administration of amiloride. This drug produced an increase in the magnitude of the positive PD i...

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Bibliographic Details
Published in:Pflügers Archiv 1976-01, Vol.361 (3), p.251-254
Main Author: Barratt, L J
Format: Article
Language:English
Subjects:
Amiloride - pharmacology
Animals
Epithelium - metabolism
Kidney Tubules, Distal - drug effects
Kidney Tubules, Distal - physiology
Male
Membrane Potentials - drug effects
Microelectrodes
Potassium - metabolism
Pyrazines - pharmacology
Rats
Rats, Inbred Strains
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Summary:Microelectrodes with relatively large tips (3-5 mu O.D.) were used to measure the transepithelial potential difference (PD) of the distal tubule of the rat kidney in the control state and following i.v. administration of amiloride. This drug produced an increase in the magnitude of the positive PD in early distal segments (from +8.0 to +10.5 mV) and a change in polarity of the PD in late distal segments (from -18.0 to +2.5 mV). These data suggest that the potassium-conserving properties of the drug are due to its ability to induce an unfavorable electrochemical gradient opposing passive potassium secretion along the distal tubule.
ISSN:0031-6768
1432-2013
DOI:10.1007/BF00587289