2-(α-Hydroxybenzyl)-benzimidazolium Salts and their Influence on Cultured Cells infected with Poliovirus

1 -ALKYL-2 - (α - HYDROXYBENZYL ) - BENZIMIDAZOLES (I) give a high degree of protection against the cell degeneration which follows infection of tissue cultures with poliovirus (types 1, 2 and 3) 1 . The action of corresponding quaternary salts (II) is of considerable interest in view of: ( a ) the...

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Bibliographic Details
Published in:Nature (London) 1963-12, Vol.200 (4911), p.1101-1103
Main Authors: O'SULLIVAN, D. G., WALLIS, A. K.
Format: Article
Language:English
Subjects:
Antiviral Agents
Benzimidazoles
Cell Line
Humanities and Social Sciences
Iodides
letter
multidisciplinary
Old Medline
Pharmacology
Poliovirus
Research Design
Salts
Science
Science (multidisciplinary)
Tissue Culture Techniques
Virus Cultivation
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Summary:1 -ALKYL-2 - (α - HYDROXYBENZYL ) - BENZIMIDAZOLES (I) give a high degree of protection against the cell degeneration which follows infection of tissue cultures with poliovirus (types 1, 2 and 3) 1 . The action of corresponding quaternary salts (II) is of considerable interest in view of: ( a ) the much greater solubility of these compounds in water; ( b ) the introduction of the positive charge; ( c ) the removal of the type of hydrogen-bonding (III) or metalchelating (IV) propensities that might (for example, by allowing attachment to protein or nucleic acid) play some part in the activity of the parent compound HBB (I; R = H) and of its 1-alkyl derivatives (I; R = alkyl). Infra-red spectra show that these latter compounds form pairs of intermolecular hydrogen-bonded links as indicated (III), and they also form copper chelates.
ISSN:0028-0836
1476-4687
DOI:10.1038/2001101b0