Possible involvement of central histamine H2-receptors in the hypotensive effect of clonidine

CLONIDINE and some other antihypertensive drugs exert their effect by acting on the central nervous system 1–4 . Some α-adrenoceptor blocking drugs antagonise the centrally mediated hypotensive effect of clonidine 5–7 . It has therefore been suggested that clonidine acts by stimulating central α-adr...

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Published in:Nature (London) 1976-02, Vol.259 (5544), p.587-588
Main Authors: KARPPANEN, HEIKKI, PAAKKARI, ILARI, PAAKKARI, PIRKKO, HUOTARI, RAIMO, ORMA, ANNA-LIISA
Format: Article
Language:English
Subjects:
Blood Pressure - drug effects
Brain - drug effects
Brain - metabolism
Clonidine - antagonists & inhibitors
Clonidine - pharmacology
Histamine - metabolism
Humanities and Social Sciences
letter
Metiamide - pharmacology
multidisciplinary
Receptors, Drug
Science
Science (multidisciplinary)
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Summary:CLONIDINE and some other antihypertensive drugs exert their effect by acting on the central nervous system 1–4 . Some α-adrenoceptor blocking drugs antagonise the centrally mediated hypotensive effect of clonidine 5–7 . It has therefore been suggested that clonidine acts by stimulating central α-adrenoceptors, bringing about a depression of the cardiovascular system. The involvement of classical α-adreno-ceptors has, however, been challenged 8,9 . Moreover, in the brain tissue clonidine may even be a potent α-adrenoceptor antagonist 10 .
ISSN:0028-0836
1476-4687
DOI:10.1038/259587a0