Nickel-epidermal interactions: Diffusion and binding

To elucidate some of the variables associated with nickel contact allergy, the diffusion of nickel through the epidermis and the binding of nickel to the epidermis were investigated. Diffusion of 63Ni through the epidermis from solutions of surfactants was found to be slight. Considerable amounts of...

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Bibliographic Details
Published in:Environmental research 1976-02, Vol.11 (1), p.34-39
Main Authors: Samitz, M.H., Katz, S.A.
Format: Article
Language:English
Subjects:
Binding Sites
Diffusion
Humans
Nickel - metabolism
Skin - metabolism
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Summary:To elucidate some of the variables associated with nickel contact allergy, the diffusion of nickel through the epidermis and the binding of nickel to the epidermis were investigated. Diffusion of 63Ni through the epidermis from solutions of surfactants was found to be slight. Considerable amounts of nickel, however, were bound to the epidermis. An epidermis powder was prepared, and selected functional groups were inactivated by chemical means. The nickel uptake of these modified epidermis powders as compared to the untreated material indicates that carboxyl groups are involved in the binding of nickel to a greater extent than are amino groups.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(76)90108-0