Left ventricular function and adrenergic hyperactivity before and after saphenous vein bypass

Forty patients with severe angina pectoris were studied before and two weeks after saphenous vein bypass surgery (SVG) in order to assess the effect of this operation on left ventricular performance as judged by systolic time intervals (STI). The patients were divided into two groups: group I includ...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1976-05, Vol.53 (5), p.802-806
Main Authors: Boudoulas, H, Lewis, R P, Vasko, J S, Karayannacos, P E, Beaver, B M
Format: Article
Language:English
Subjects:
Adult
Angina Pectoris - physiopathology
Angina Pectoris - surgery
Electrocardiography
Epinephrine - urine
Female
Heart - physiopathology
Heart Ventricles - physiopathology
Humans
Male
Norepinephrine - urine
Saphenous Vein - transplantation
Time Factors
Transplantation, Autologous
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Summary:Forty patients with severe angina pectoris were studied before and two weeks after saphenous vein bypass surgery (SVG) in order to assess the effect of this operation on left ventricular performance as judged by systolic time intervals (STI). The patients were divided into two groups: group I included 29 patients in whom no postoperative infarction occurred and group II was composed of 11 patients with postoperative infarction. For group I the PEP/LVET was 0.39 +/- 0.01 preop and slightly but significantly increased at 0.42 +/- 0.004 (P less than 0.025) two weeks postop. The mean preop PEP/LVET was 0.33 +/- 0.01 for group II and dramatically increased to 0.54 +/- 0.02 (P less than 0.001) after surgery. Another striking abnormally was a marked shortening of electromechanical systole (QS2I), which was uniformly present in the postoperative studies. Follow-up studies in 16 patients and urinary catecholamine determination in five patients suggested excessive adrenergic activity was responsible for the abbreviated QS2I. This phenomenon must be considered when interpreting the results of SVG on left ventricular function.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.53.5.802