Lithium inhibition of adrenaline-stimulated adenylate cyclase in humans

LITHIUM is an effective therapeutic agent in the treatment and prevention of the manic phase of manic-depression 1 , and although known to influence many physiological systems, no specific mechanism has been identified for its efficacy in this illness 2 . One postulated primary site of Li action is...

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Bibliographic Details
Published in:Nature (London) 1976-02, Vol.259 (5542), p.411-413
Main Authors: EBSTEIN, RICHARD, BELMAKER, ROBERT, GRUNHAUS, LEON, RIMON, RANAN
Format: Article
Language:English
Subjects:
Adenylyl Cyclases - metabolism
Affective Symptoms - drug therapy
Cyclic AMP - blood
Enzyme Activation - drug effects
Epinephrine - antagonists & inhibitors
Humanities and Social Sciences
Humans
letter
Lithium - pharmacology
Lithium - therapeutic use
multidisciplinary
Science
Science (multidisciplinary)
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Summary:LITHIUM is an effective therapeutic agent in the treatment and prevention of the manic phase of manic-depression 1 , and although known to influence many physiological systems, no specific mechanism has been identified for its efficacy in this illness 2 . One postulated primary site of Li action is as an inhibitor of hormone-stimulated adenylate cyclase 3 . Li inhibits the ADH-sensitive adenylate cyclase in kidney 4,5 , the TSH-sensitive adenylate cyclase in thyroid 6,7 , the prostaglandin-sensitive adenylate cyclase in human platelets 8,9 , and the noradrenaline-sensitive adenylate cyclase in rat brain 10,11 .
ISSN:0028-0836
1476-4687
DOI:10.1038/259411a0